Circulation levels of YKL-40 and Hs-CRP in stage 3 Molar-incisor pattern of periodontitis

Authors

  • Zeynep Pinar Keles Yucel
  • Umut Balli

Keywords:

Acute-phase proteins, C-reactive protein, human, periodontal diseases, serum, YKL 40 protein   

Abstract

Aim: To evaluate the novel acute phase protein YKL-40 and high-sensitive C-reactive protein (Hs-CRP) in serum of patients with molar-incisor pattern of periodontitis (Stage 3, Grade C).Material and Methods: Twenty seven patients with molar-incisor pattern of periodontitis and 27 periodontally healthy individuals were included into the study. Serum levels of YKL-40 and Hs-CRP were measured by enzyme-linked immunosorbent assay.Results: Serum YKL-40 levels were significantly increased in molar-incisor pattern of periodontitis patients compared to healthy controls (P0.05). Similarly, significantly higher serum Hs-CRP levels were found in the patients with molar-incisor pattern of periodontitis than those of healthy ones (P0.05). There were positive correlations between serum YKL-40 and Hs-CRP and BOP in healthy control group (P0.05 for all). Moreover, serum YKL-40 showed positively strong relationships with Hs-CRP and also clinical periodontal parameters (CAL and BOP) in the periodontitis group (P0.001 for all).Conclusion: The present data suggest that YKL-40 might be a candidate biomarker for the diagnosis of localized to molar-incisor pattern of periodontitis and may also have the potential to predict the future risk of systemic diseases for this distinct form of periodontitis.

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Published

2021-05-25

Issue

Section

Original Articles

How to Cite

1.
Circulation levels of YKL-40 and Hs-CRP in stage 3 Molar-incisor pattern of periodontitis . Ann Med Res [Internet]. 2021 May 25 [cited 2025 Apr. 3];27(5):1362-8. Available from: http://annalsmedres.org/index.php/aomr/article/view/775