The association between CGRP gene -624 T→C polymorphism and headache severity in Turkish migraine patients

Authors

  • Ebru Etem Onalan Fırat University, Faculty of Medicine, Department of Medical Biology and Genetics, Elazığ, Türkiye
  • Sezgin Cetin Fırat University, Faculty of Medicine, Department of Medical Biology and Genetics, Elazığ, Türkiye
  • Seda Kosan Fırat University, Faculty of Medicine, Department of Neurology, Elazığ, Türkiye
  • Halit Elyas Fırat University, Faculty of Medicine, Department of Medical Biology and Genetics, Elazığ, Türkiye
  • Bulent Mungen Fırat University, Faculty of Medicine, Department of Neurology, Elazığ, Türkiye

Keywords:

Migraine, CGRP, Gene polymorphism

Abstract

Aim: This study aims to explore -624 T→C polymorphism on CGRP gene in migraine patients, and the relation between this polymorphism and migraine attacks.

Materials and Methods: The study registered a total of 101 migraine patients, 17 with aura and 84 without aura and 80 healthy volunteers. CGRP -624 T→C polymorphism in migraine patients and the control group was evaluated using PCR-RFLP method.

Results: Although no significant difference could be found between genotype and allele frequencies of CGRP -624T→C polymorphism in the patient and control groups (p>0.05). In addition, a statistically significant positive correlation was established between the severity of headache and C allele of this gene in migraine patients (p<0.05).

Conclusion: The fact that C allele of CGRP gene is at a higher rate in those with severe migraine attacks suggests that this allele can render neuroinflammation more marked by increasing the amount of CGRP. However, how CGRP -624T→C polymorphism influences the expressian level of the gene is not known for sure yet.

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Published

2024-03-25

Issue

Vol. 31 No. 3 (2024): March

Section

Original Articles

License

Copyright (c) 2024 Annals of Medical Research

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

CC Attribution-NonCommercial-NoDerivatives 4.0

How to Cite

1.
The association between CGRP gene -624 T→C polymorphism and headache severity in Turkish migraine patients. Ann Med Res [Internet]. 2024 Mar. 25 [cited 2025 Feb. 23];31(3):211-5. Available from: http://annalsmedres.org/index.php/aomr/article/view/4647