Prognostic markers in operated non-small cell lung cancer patients

Abstract

Aim: The overall survival (OS) of operable lung cancer patients is directly related to clinicopathological features and some laboratory parameters. In this study, we aimed to examine the factors affecting the survival of the operated patients.

Materials and Methods: In our study, we retrospectively analyzed 202 operated-on patients diagnosed with lung carcinoma who were in stages I–IIIA at the time of diagnosis. The clinico-pathological features and some laboratory parameters of the patients included in our study were retrospectively analyzed. The effects of those parameters on the overall survival of the patients and their disease-free survival (DFS) have been investigated.

Results: The age of the patient at the time of diagnosis and the presence of lymphovascular invasion (LVI) were found to be statistically significant in terms of OS (p<0,05). Pathological tumor size, LVI, and peri-neural invasion (PNI) parameters were statistically significant for DFS. In addition, neutrophil-lymphocyte ratio (NLR), which is an inflammatory indicator, is an important parameter with statistical significance in terms of both OS and DFS (p<0,05).

Conclusions: Our study yielded that LVI and PNI parameters would be beneficial to estimate patients' survival and prognosis. In addition, NLR was observed to have a statistically significant effect on OS and DFS.