Efficacy of nivolumab as second-line treatment for elderly patients with metastatic malign melanoma

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Oktay Unsal
Ozan Yazici
Nuriye Ozdemir
Ahmet Ozet

Abstract

Aim:  This study aimed to analyse the clinical characteristics, effectiveness and safety of nivolumab monotherapy in patients aged≥ 65 years with metastatic melanoma.


Materials and Methods: This study involved patients aged ≥65 years who were diagnosed with metastatic cutaneous or mucosal melanoma. Patients with BRAF wild type, ECOG performance status 0-1, and who had previously received one line of chemotherapy were included, irrespective of PD-L1 expression. The study analyzed PFS, OS, and adverse event profiles.


Results: Twenty-one patients, with a median age of 70, were analysed in the study. The median PFS for nivolumab as second-line therapy in elderly patients was 3.5 months (95% CI, 1.5 to 5.6 months), while the median OS was 14.5 months (95% CI, 10.3 to 18.6 months). The most common grade 1-2 adverse events were anemia (66.7%) and serum creatinine increase (23.8%). Additionally, the rate of grade 3-4 adverse events due to all causes was 28.6%. There was no grade 5 adverse event.


Conclusion: Nivolumab is effective and safe as second-line therapy in patients aged ≥65 years with metastatic melanoma. It is a tolerable and effective treatment choice for elderly patients who cannot received nivolumab in first line therapy.

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How to Cite
Unsal, O., Yazici, O., Ozdemir, N., & Ozet, A. (2023). Efficacy of nivolumab as second-line treatment for elderly patients with metastatic malign melanoma. Annals of Medical Research, 30(8), 965–969. Retrieved from http://annalsmedres.org/index.php/aomr/article/view/4502
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