Hepatoprotective effect of pycnogenol in gentamicin-induced liver injury in rats

Authors

  • Tuba Ozcan Metin Kahramanmaras Sutcu Imam University, Faculty of Medicine, Department of Histology and Embryology, Kahramanmaras, Türkiye

Keywords:

Betatrophin, Caspase-3, Fibrillin-1, Gentamicin, Liver injury, Pycnogenol

Abstract

Aim: The present study aimed to investigate the possible hepatoprotective effect pycnogenol (PYC) in gentamicin (GEN)-induced liver injury in rats.

Materials and Methods: The study consisted of four groups of seven rats; control, PYC (20 mg/kg for 8 days), GEN (80 mg/kg for 8 days) and GEN+PYC. At the end of the experiment, liver tissues of all groups were collected for histopathological and immunohistochemical (fibrillin-1, caspase-3, and betatrophin antibodies) evaluation.

Results: Histopathological analysis revealed that the GEN treated group had liver damage as a result of the GEN administration compared to the control group. Additionally, fibrillin-1, caspase-3, and betatrophin expression all increased in rat liver tissues. However, PYC pretreatment significantly reduced the expression of the aforementioned antibodies and mitigated liver damage.

Conclusion: The anti-apoptotic and antioxidant properties of PYC may help to preserve liver histoarchitecture against GEN-induced hepatotoxicity.

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Published

2023-03-24

Issue

Vol. 30 No. 3 (2023): March

Section

Original Articles

License

Copyright (c) 2023 Annals of Medical Research

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

CC Attribution-NonCommercial-NoDerivatives 4.0

How to Cite

1.
Hepatoprotective effect of pycnogenol in gentamicin-induced liver injury in rats. Ann Med Res [Internet]. 2023 Mar. 24 [cited 2025 Feb. 23];30(3):370-4. Available from: http://annalsmedres.org/index.php/aomr/article/view/4386