Investigation of biomarker properties of DARS2 to distinguish squamous cell carcinoma from keratoacanthoma

Authors

  • Ozlem Ucer Firat University, Faculty of Medicine, Department of Pathology, Elazig, Türkiye
  • Nevin Kocaman Firat University, Faculty of Medicine, Department of Histology and Embryology, Elazig, Türkiye

Keywords:

Squamous cell carcinoma, Keratoacanthoma, Immunohistochemistry, DARS2

Abstract

Aim: This study was aimed at investigating the effectiveness of DARS2 protein expression in the differential diagnosis of squamous cell carcinoma (SCC) and keratoacanthoma (KA).

Materials and Methods: A total of 60 cases, 30 SCC and 30 KA, diagnosed in the Fırat University, Faculty of Medicine, Department of Pathology, were analysed immunohistochemically by studying the DARS2 protein.

Results: DARS2 expression values were found to be statistically significant in the differential diagnosis of SCC and KA (p<0.05).

Conclusion: The marker used in this study was found useful in the differential diagnosis of SCC and KA, and it is recommended that, further molecular and genetic studies be carried out, this will facilitate the accurate diagnosis of SCC from KA.

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Published

2022-10-22

Issue

Vol. 29 No. 10 (2022): October

Section

Original Articles

License

Copyright (c) 2022 Annals of Medical Research

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

CC Attribution-NonCommercial-NoDerivatives 4.0

How to Cite

1.
Investigation of biomarker properties of DARS2 to distinguish squamous cell carcinoma from keratoacanthoma. Ann Med Res [Internet]. 2022 Oct. 22 [cited 2025 Feb. 23];29(10):1114-7. Available from: http://annalsmedres.org/index.php/aomr/article/view/4300