Hippocampal damage in sepsis induced by lipopolysaccharide: The neuroprotective effects of pregabalin in a rat model

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Rahime Aslankoc
Ozlem Ozmen

Abstract

Aim: An excessive immune response to bacterial infections can lead to sepsis, a condition with a high mortality rate. Lipopolysaccharide (LPS)-induced inflammation and oxidative stress cause hippocampal injury. We aimed to investigate the antioxidant, anti-inflammatory and neurogenic effects of pregabalin (PG) against hippocampal injury induced by LPS.
Material and Methods: Twenty-four rats were divided into three different groups (Control, LPS (5 mg/kg), and LPS+PG (30 mg/kg)). Six hours after LPS administration, animals were sacrificed, and the hippocampus tissue was gathered for biochemical, histopathological, and immunohistochemical research.
Results: Biochemical and immunohistochemical analyses revealed the increased levels of total oxidant status (TOS), oxidative stress index (OSI), tumor necrosis factor alpha (TNF-α), interleukin-1β (IL-1β) and decreased expressions of total antioxidant status (TAS), brain-derived neurotrophic factor (BDNF), and sirtuin-1 (SIRT-1) in LPS group. In addition, histopathological analyses detected degenerative neurons, hyperemia, and edema.
Conclusion: PG treatment reversed biochemical and immunohistochemical parameters and improved hyperemia, edema, and degenerative changes. In conclusion, PG increased BDNF and SIRT-1 levels by inhibiting inflammation and oxidative stress.

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How to Cite
Aslankoc, R., & Ozmen, O. (2022). Hippocampal damage in sepsis induced by lipopolysaccharide: The neuroprotective effects of pregabalin in a rat model. Annals of Medical Research, 29(1), 0077–0082. Retrieved from http://annalsmedres.org/index.php/aomr/article/view/4027
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Original Articles