Oxidant and antioxidant levels in patients diagnosed with acute coronary syndrome at the emergency department

Authors

  • Selma Tekkanat Department of Emergency Medicine, Yuksekova State Hospital, Hakkari, Turkey
  • Nalan Kozaci Department of Emergency Medicine, Alanya Education and Research Hospital, Alanya Alaaddin Keykubat University, Antalya,Turkey
  • Mustafa Avci Department of Emergency Medicine, Antalya Education and Research Hospital, University of Health Sciences, Antalya, Turkey
  • Fatih Selvi Department of Emergency Medicine, Antalya Education and Research Hospital, University of Health Sciences, Antalya, Turkey
  • Yavuz Yilmaz Department of Emergency Medicine, Basaksehir City Hospital, IstanbulTurkey
  • Hamit Yasar Ellidag Department of Medical Biochemistry, Antalya Education and Research Hospital, University of Health Sciences, AntalyaTurkey

Keywords:

Acute coronary syndrome, coronary angiography, myocardial infarction, total antioxidant capacity, total oxidant capacity

Abstract

Aim: The aim of this study is to compare high sensitive Troponin T (hs-TnT), total antioxidant capacity (TAC), total oxidant capacity
(TOC), oxidative stress index (OSI), ischemia-modified albumin (IMA) levels and IMA/albumin ratios (IMAR) with the results of
coronary angiography (CAG) in patients diagnosed with ACS at the emergency department.
Materials and Methods: Over a period of nine months, patients that were diagnosed with ACS at the emergency department, admitted
to the cardiac intensive care unit, subjected to percutaneous CAG and over the age of 18 were included in the study.
Results: One hundred twenty five patients with suspected ACS and 52 healthy volunteers were included in the study. When the
patients were evaluated with regards to the length of time between symptoms and arrival, TAC levels were found to decrease
especially after the 6 th hour. There was no significant difference between TOC, OSI, IMA and IMAR values in this regard.
Conclusion: In early-phase ACS, levels of TOC, OSI, IMA and IMAR rise from the 0th hour onwards. TAC levels gradually decrease
after the early phase of ischemia. Therefore, oxidants and antioxidants can be used for early diagnosis of ischemia in ACS, as well
as for estimating time of ischemia onset.

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Published

2021-06-28

Issue

Vol. 28 No. 6 (2021): June

Section

Original Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

CC Attribution-NonCommercial-NoDerivatives 4.0

How to Cite

1.
Oxidant and antioxidant levels in patients diagnosed with acute coronary syndrome at the emergency department. Ann Med Res [Internet]. 2021 Jun. 28 [cited 2025 Feb. 23];28(6):1235-40. Available from: http://annalsmedres.org/index.php/aomr/article/view/3813