Effects of bosentan, sildenafil and their combination on T-wave amplitude and QT ınterval in a rat model of pulmonary hypertension

Authors

  • Derya Karpuz
  • Olgu Hallioglu
  • Belgin Buyukakilli
  • Serkan Gurgul
  • Bahar Tasdelen

Keywords:

s: Pulmonary Arterial Hypertension, Rat Model, Sildenafil, Bosentan, Electrocardiography, Echocardiography.

Abstract

Aim: Although, bosentan and sildenafil have been used to treat PAH, the effect of these drugs on electrocardiographic (ECG) changes are still unclear. The aim of this study is to evaluate the effects of bosentan, sildenafil, and their combination on T-wave amplitude and QT interval in rats with monocrotaline (MCT)-induced PAH.

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Published

2021-05-25

Issue

Vol. 24 No. 1 (2017): March

Section

Original Articles

License

CC Attribution-NonCommercial-NoDerivatives 4.0

How to Cite

1.
Effects of bosentan, sildenafil and their combination on T-wave amplitude and QT ınterval in a rat model of pulmonary hypertension . Ann Med Res [Internet]. 2021 May 25 [cited 2025 Feb. 23];24(1):0037-43. Available from: http://annalsmedres.org/index.php/aomr/article/view/2158