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Formerly Journal of Turgut Ozal Medical Center - ISSN 1300-1744

  • Annals of Medical Research



    Annals of Medical Research International Monthly Published Medical Journal

  • Annals of Medical Research

    In publication or citation search, the name similarities of the authors, typographical errors and institutional changes can cause confusion. To prevent this, researchers need to obtain a descriptive ID. ORCID (Open Researcher and Contributor ID) is a researcher-specific international URI with a 16-digit number. You can register for free for individual ORCID at http://orcid.org. Please indicate the ORCID number of all authors when submitting your article.

  • Annals of Medical Research


    Annals of Medical Research indexed in TÜBİTAK/ULAKBİM Tıp Veri Tabanı

  • Annals of Medical Research


    Annals of Medical Research indexed in

  • Annals of Medical Research
  • Annals of Medical Research
  • Annals of Medical Research
  • Annals of Medical Research

Dear readers,

Our journal is the official publication of Inonu University Medical Faculty and published uninterruptedly for 25 years. It was first published as the name of Inonu University Medical Journal and later as Journal of Turgut Ozal Medical Center. During its publication period, the journal accepted Turkish or English articles for publication.

Abstracting in an international index is just a paramount objective in the 25th year of the journal. Because of this goal, it was necessary to make a decision both in terms of journal name and publication language. It was important in this respect that the name of a general medical journal should be related to medicine again and it should be in English. For these reasons, the name of the journal was switched to Annals of Medical Research and its publication language is changed to in English. The logo of the journal was chosen as an apricot, which is the symbol of our city Malatya, the world capital of apricot. I hope the journal succeeds with its new name. Annals of Medical Research is It is published monthly.

Editor-in-Chief
Cuneyt Kayaalp

 

Survival analysis of single agent gemcitabine therapy in patients with metastatic breast cancer (p. 1773-6)

Survival analysis of single agent gemcitabine therapy in patients with metastatic breast cancer (p. 1773-6)

Havva Yesil Cinkir1, Gokmen Aktas2
1 Gaziantep University, Faculty of Medicine, Department of Internal Medicine, Division of Medical Oncology, Gaziantep, Turkey
2 Kahramanmaras Sutcu Imam University, Faculty of Medicine, Department of Internal Medicine, Division of Medical Oncology, Kahramanmaras, Turkey

Abstract

Aim: Gemcitabine has demonstrated experimental and clinical antitumor activity in various human neoplasms including pancreas, ovary, non-small cell lung and breast tumors. We aimed to investigate the factors affecting progression-free survival (PFS) and overall survival (OS) of patients who received single agent gemcitabine for metastatic breast cancer.
Material Methods: Twenty-eight patients with metastatic breast cancer who were treated with gemcitabine in Gaziantep University Medical Faculty Medical Oncology Department between March 2007 and December 2018 were evaluated retrospectively. Gemcitabine 1000 mg / m2 was administered as a single agent treatment on the 1st and 8th days, every 21 days.
Results: Twenty-seven (96.4%) of the patients were female and 1 (3.6%) was male. The median age was 52 years(range 35-76). Median PFS was 5 months (95% confidence interval 2,41-7,58) and median OS was 26 months (95% confidence interval 11,73-40,26). The median PFS of the patients with only lung metastasis was 16 months and the other patients were 4 months (Log-rank p = 0.020)
Conclusion: Gemcitabine is a very well tolerated agent with sufficient efficacy for patients with metastatic breast cancer who were preferred to use single agent chemotherapy than combination therapies. Patients with only lung metastasis may benefit more from single agent gemcitabine in metastatic breast cancer.
Keywords: Metastatic breast cancer; gemcitabine; progression-free survival; overall survival.

 

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doi: 10.5455/annalsmedres.2019.08.460

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Turkey


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Annals of Medical Research is the scientific official journal of the Inonu University Faculty of Medicine. It is published monthly. The essential aim of the Annals of Medical Research is to publish scientifically high quality clinical and experimental research articles on fields of medicine which can contribute to the literature data. In addition, review articles, case reports, editorials, letters to the editors and manuscripts on publication ethics and medical history, which can contribute to the education and practices of physicians and health sector professionals within the scope of the journal’s target audience and which can increase the level of scientific communication between the authors and readers, are included in the scope of the journal.

 

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