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Formerly Journal of Turgut Ozal Medical Center - ISSN 1300-1744

  • Annals of Medical Research



    Annals of Medical Research International Monthly Published Medical Journal

  • Annals of Medical Research

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  • Annals of Medical Research


    Annals of Medical Research indexed in TÜBİTAK/ULAKBİM Tıp Veri Tabanı

  • Annals of Medical Research


    Annals of Medical Research indexed in

  • Annals of Medical Research
  • Annals of Medical Research
  • Annals of Medical Research
  • Annals of Medical Research

Dear readers,

Our journal is the official publication of Inonu University Medical Faculty and published uninterruptedly for 25 years. It was first published as the name of Inonu University Medical Journal and later as Journal of Turgut Ozal Medical Center. During its publication period, the journal accepted Turkish or English articles for publication.

Abstracting in an international index is just a paramount objective in the 25th year of the journal. Because of this goal, it was necessary to make a decision both in terms of journal name and publication language. It was important in this respect that the name of a general medical journal should be related to medicine again and it should be in English. For these reasons, the name of the journal was switched to Annals of Medical Research and its publication language is changed to in English. The logo of the journal was chosen as an apricot, which is the symbol of our city Malatya, the world capital of apricot. I hope the journal succeeds with its new name. Annals of Medical Research is It is published monthly.

Editor-in-Chief
Cuneyt Kayaalp

 

Decreased levels of plasma preptin in female patients with knee osteoarthritis (p. 1805-8)

Decreased levels of plasma preptin in female patients with knee osteoarthritis (p. 1805-8)

Murat Cakir1, Seda Sabah Ozcan2, Murat Korkmaz3, Serhat Durusoy3
1Yozgat Bozok University, Faculty of Medicine, Department of Physiology, Yozgat, 66200, Turkey
2Yozgat Bozok University, Faculty of Medicine, Department of Medical Biology, Yozgat, 66200, Turkey
3Yozgat Bozok University, Faculty of Medicine, Department of Orthopedics and Traumatology, Yozgat, 66200, Turkey

Abstract

Aim: Osteoarthritis (OA) is a common joint disease which is caused by the effects of mechanical, genetic and biochemical factors. In studies conducted in recent years, it has been shown that osteoblasts play roles in OA pathogenesis. In this study, we investigated the relation between the level of preptin, which is known to have an effect on osteoblast proliferation and differentiation, bone metabolism, and the OA disease.
Materials and Methods: A total of 40 healthy control patients and 40 women who were diagnosed with knee OA were included in the present study. The plasma preptin levels of the individuals who were included in the study were measured with Enzyme-linked Immuno-Sorbent Assay (ELISA) Method. Blood glucose, triglyceride, High-Density Lipoprotein Cholesterol (HDL-c), Low-Density Lipoprotein Cholesterol (LDL-c), total cholesterol levels and Body Mass Indices (BMI) leukocyte, lymphocyte, neutrophil, Erythrocyte Sedimentation Rate (ESR), C-Reactive Protein (CRP) of all participants were measured.
Results: The preptin levels of the knee OA patients in plasma were significantly lower (206 ± 103 ng/L) compared to the healthy control Group (501 ± 525 ng/L) (p0.001). In addition, the (CRP) levels (p0.02) and the Body Mass Indices (BMI) (p0.001) were also higher in the OA Group compared to the Control Group.
Conclusion: In the present study, it was determined that there is a significant relation between knee OA disease and plasma preptin levels. Preptin may have roles in the pathogenesis of the OA disease. Further studies are needed to elucidate the mechanisms through which molecular mechanisms preptin is related to knee OA.
Keywords: Osteoarthritis; knee; preptin; ELISA; plasma. 

 

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doi: 10.5455/annalsmedres.2019.07.418

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Annals of Medical Research is the scientific official journal of the Inonu University Faculty of Medicine. It is published monthly. The essential aim of the Annals of Medical Research is to publish scientifically high quality clinical and experimental research articles on fields of medicine which can contribute to the literature data. In addition, review articles, case reports, editorials, letters to the editors and manuscripts on publication ethics and medical history, which can contribute to the education and practices of physicians and health sector professionals within the scope of the journal’s target audience and which can increase the level of scientific communication between the authors and readers, are included in the scope of the journal.

 

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