1Kahramanmaras Sutçuimam University, Faculty of Medicine, Department of Pediatrics, Kahramanmaras Turkey
2sivas Numune Training And Research Hospital, Clinic of Pediatric Allergy and Immunology, Sivas, Turkey
3Sivas Numune Training And Research Hospital, Clinic of Pharmacology, Sivas, Turkey
Aim: Familial Mediterranean fever (FMF); is an auto-inflammatory disease characterized by recurrent fever attacks. Inflammation continues even in the attack-free period. Monocyte to high-density lipoprotein cholesterol (HDL-C) ratio (MHR) is an inflammatory marker that has recently begun to use. The aim of the study was to evaluate the relationship between MHR and FMF in children.
Material and Methods: Sixty-two children with FMF in the attack-free period and 60-age and sex-matched- healthy controls included in the study. Patients divided into subgroups according to their gene mutation type. Monocyte count and HDL-C levels retrieved from medical records of patients and MHR were calculated from these data.
Results: The MHR of individuals were close to each other and there was no statistically significant difference between them ( p>0.05). Twenty-four of the patients had heterozygous, 4 had homozygous, 11 had a compound and 21 had negative mutations. Two of the patients had no mutation analysis. There was no significant difference between these four groups according to MHR (p=0.348). However, MHR revealed a positive correlation with fibrinogen (r=0.604, p0.005, n=24), serum amyloid A (r=0.437, p=0.005, n=39), C-reactive protein (r=0.277, p=0.005, n=101), and erythrocyte sedimentation rate (r=0.404, p0.001, n=104).
Conclusion: As a result, we showed MHR was not different from healthy controls in FMF patients. Contrary to what is claimed, the use of MHR as an inflammatory marker in FMF is doubtful.
Keywords: Monocyte hdl ratio; familial mediterranean fever; inflammation marker.