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  • Annals of Medical Research



    Annals of Medical Research International Monthly Published Medical Journal

  • Annals of Medical Research

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  • Annals of Medical Research
  • Annals of Medical Research
  • Annals of Medical Research
  • Annals of Medical Research

Dear Annals of Medical Research Readers

As of the end of March 2021, I have started to work as Chief Editor at Annals of Medical Research. Our journal is the official publication of Inonu University Medical Faculty and published uninterruptedly for 28 years.  Our Journal, which is online as an open access journal with monthly free access, is being scanned in many national and international indexes (ULAKBIM TR Dizin, Turkish Medline, EBSCO, Google Scholar, etc.). I would like to thank the Editors before me who contributed to this level. Our primary goal is to ensure the maintenance of this good state of the journal and to ensure that it is scanned in prestigious international indexes (Pubmed Central, SCI-Expended, etc.). In order to achieve these goals, it depends on the original research articles that can be cited and the articles published in our Journal to be cited sufficiently in other international journals. The contributions of our readers, reviewers and authors in achieving this goal are of great importance.

I hope to announce the news that we have reached our goals as soon as possible.

MD. Prof. Nevzat Erdil

Editor-in-Chief

Annals of Medical Research

 

The prognostic role of the pretreatment peripheral neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) in patients with cervical cancer (p.778-85)

The prognostic role of the pretreatment peripheral neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) in patients with cervical cancer (p.778-85)

Sefika Arzu Ergen1, Ceren Barlas1, Meltem Dagdelen1, Gunay Can2, Ismet Sahinler1
1Department of Radiation Oncology, Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Istanbul, Turkey
2Department of Public Health, Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Istanbul, Turkey
Copyright@Author(s) - Available online at www.annalsmedres.org
Content of this journal is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Abstract

Aim: To investigate whether pretreatment peripheral neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) can be used as a prognostic indicator for predicting treatment response and survival outcomes in patients with cervical cancer.
Materials and Methods: Records of 141 patients with histologic confirmation of squamous cell carcinoma of the uterine cervix who were treated with radical radiotherapy or chemoradiotherapy in our clinic from 2010 to 2016 were retrospectively reviewed in this study. The relationship between pretreatment NLR/PLR with clinicopathological characteristics and therapeutic response and survival was analyzed. The cut-off values of NLR and PLR that predicted treatment response were determined using a receiver operating characteristic analysis.
Results: In the clinicopathological analysis, while pretreatment elevated NLR was associated with the tumor size and grade, elevated PLR was related to an advanced stage, tumor size and grade. Low NLR (2.64) and PLR (164) predicted treatment response significantly. However, there was no relationship between NLR/PLR and survival outcomes. The five-year overall survival (OS) and progression-free survival (PFS) rates for the whole study group were 67% and 74%, respectively. In multivariate analysis, the presence of the lymph node involvement and incomplete response to treatment was independent prognostic factors affecting both OS (p = 0.013, p 0.001) and PFS (p = 0.004, p 0.001).
Conclusion: Pretreatment NLR/PLR has predicted the treatment response significantly. The optimal cut-off values confirmed by further large-scale studies may be used in the future as a predictive marker for therapeutic response in cervical cancer.

Keywords: Cervical cancer; neutrophil/lymphocyte ratio; platelet/lymphocyte ratio; radiotherapy; concurrent chemoradiotherapy

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doi: 10.5455/annalsmedres.2020.12.1190    

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Annals of Medical Research is the scientific official journal of the Inonu University Faculty of Medicine. It is published monthly. The essential aim of the Annals of Medical Research is to publish scientifically high quality clinical and experimental research articles on fields of medicine which can contribute to the literature data. In addition, review articles, case reports, editorials, letters to the editors and manuscripts on publication ethics and medical history, which can contribute to the education and practices of physicians and health sector professionals within the scope of the journal’s target audience and which can increase the level of scientific communication between the authors and readers, are included in the scope of the journal.

 

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