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Formerly Journal of Turgut Ozal Medical Center

  • Annals of Medical Research



    Annals of Medical Research International Monthly Published Medical Journal

  • Annals of Medical Research

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  • Annals of Medical Research


    Annals of Medical Research indexed in TÜBİTAK/ULAKBİM Tıp Veri Tabanı

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  • Annals of Medical Research
  • Annals of Medical Research
  • Annals of Medical Research
  • Annals of Medical Research

Dear Annals of Medical Research Readers

As of the end of March 2021, I have started to work as Chief Editor at Annals of Medical Research. Our journal is the official publication of Inonu University Medical Faculty and published uninterruptedly for 28 years.  Our Journal, which is online as an open access journal with monthly free access, is being scanned in many national and international indexes (ULAKBIM TR Dizin, Turkish Medline, EBSCO, Google Scholar, etc.). I would like to thank the Editors before me who contributed to this level. Our primary goal is to ensure the maintenance of this good state of the journal and to ensure that it is scanned in prestigious international indexes (Pubmed Central, SCI-Expended, etc.). In order to achieve these goals, it depends on the original research articles that can be cited and the articles published in our Journal to be cited sufficiently in other international journals. The contributions of our readers, reviewers and authors in achieving this goal are of great importance.

I hope to announce the news that we have reached our goals as soon as possible.

MD. Prof. Nevzat Erdil

Editor-in-Chief

Annals of Medical Research

 

Age-related differences in the effect of vitamin D on scopolamine-induced learning and memory impairment (p.799-805)

Age-related differences in the effect of vitamin D on scopolamine-induced learning and memory impairment (p.799-805)

Medine Karabulut1, Ozgur Baykan2, Elif Aksoz3
1Department of Veterinary Pharmacology and Toxicology, Health Sciences Institute, Balikesir University, Balikesir, Turkey
2Department of Medical Biochemistry, Faculty of Medicine, Balikesir University, Balikesir, Turkey
3Department of Medical Pharmacology, Faculty of Medicine, Balikesir University, Balikesir, Turkey
Copyright@Author(s) - Available online at www.annalsmedres.org
Content of this journal is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Abstract

Aim: Alzheimer's disease is the most common type of dementia. The number of patients with Alzheimer's is expected to reach 115 million in 2050. Due to the low effectiveness and frequent adverse effects of current treatment approaches, expected results cannot be obtained in treatment. Vitamin D supplements are reported to have protective effects against Alzheimer's disease by increasing learning and memory performance. In this study, we aimed to evaluate the effect of vitamin D on learning and memory on cognitive deficits by scopolamine-induced memory impairment model, which is an animal model of AD, in aged rats, as well as evaluating whether the effect changes with age.
Materials and Methods: Wistar Albino male rats (Young: 4-5 months old, Aged: 21-22 months old) were used in the study. Vitamin D was given for three weeks at 500 IU/kg; scopolamine was applied 1mg/kg half an hour before behavioral experiments. Modified elevated plus maze and Morris water maze tests was performed to assess cognitive abilities during the fourth week; prefrontal cortices were then removed to assess acetylcholinesterase enzyme activity.
Results: Vitamin D administration restored memory impairment in old rats in the Morris water maze; whereas there was no effect in young group. Scopolamine significantly increased the brain prefrontal cortex AchE enzyme activity only in the young rats. Vitamin D did not create a statistically significant change in AChE activity in young rats. on the other hand, a significant increase was detected in the elderly group with vitamin D compared to the age-matched control and scopolamine groups.
Conclusion: Our results show that the effectiveness of vitamin D changes with age. Vitamin D may be a safe and effective option in preventing dementia development in the elderly group and improving cognitive dysfunction due to Alzheimer's disease.

Keywords: Vitamin D; Alzheimer’s disease; acetylcholinesterase; scopolamine; memory

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doi: 10.5455/annalsmedres.2020.11.1143

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Annals of Medical Research is the scientific official journal of the Inonu University Faculty of Medicine. It is published monthly. The essential aim of the Annals of Medical Research is to publish scientifically high quality clinical and experimental research articles on fields of medicine which can contribute to the literature data. In addition, review articles, case reports, editorials, letters to the editors and manuscripts on publication ethics and medical history, which can contribute to the education and practices of physicians and health sector professionals within the scope of the journal’s target audience and which can increase the level of scientific communication between the authors and readers, are included in the scope of the journal.

 

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