• E-ISSN 2636-7688

Formerly Journal of Turgut Ozal Medical Center

  • Annals of Medical Research

    Annals of Medical Research International Monthly Published Medical Journal

  • Annals of Medical Research

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  • Annals of Medical Research

    Annals of Medical Research indexed in TÜBİTAK/ULAKBİM Tıp Veri Tabanı

  • Annals of Medical Research

    Annals of Medical Research indexed in

  • Annals of Medical Research
  • Annals of Medical Research
  • Annals of Medical Research
  • Annals of Medical Research

Dear Annals of Medical Research Readers

As of the end of March 2021, I have started to work as Chief Editor at Annals of Medical Research. Our journal is the official publication of Inonu University Medical Faculty and published uninterruptedly for 28 years.  Our Journal, which is online as an open access journal with monthly free access, is being scanned in many national and international indexes (ULAKBIM TR Dizin, Turkish Medline, EBSCO, Google Scholar, etc.). I would like to thank the Editors before me who contributed to this level. Our primary goal is to ensure the maintenance of this good state of the journal and to ensure that it is scanned in prestigious international indexes (Pubmed Central, SCI-Expended, etc.). In order to achieve these goals, it depends on the original research articles that can be cited and the articles published in our Journal to be cited sufficiently in other international journals. The contributions of our readers, reviewers and authors in achieving this goal are of great importance.

I hope to announce the news that we have reached our goals as soon as possible.

MD. Prof. Nevzat Erdil


Annals of Medical Research


Are we on the side of over-diagnosis and treatment in  BI-RADS 4A breast lesions? (p.501-5)

Are we on the side of over-diagnosis and treatment in BI-RADS 4A breast lesions? (p.501-5)

Tevfik Avci1, Murathan Erkent1, Hale Turnaoglu2, Pelin Borcek3, Pelin Kaya2, Emre Karakaya1
1Department of General Surgery, Faculty of Medice, Baskent University, Ankara, Turkey
2Department of Radiology, Faculty of Medice, Baskent University, Ankara, Turkey
3Department of Pathology, Faculty of Medice, Baskent University, Ankara, Turkey
Copyright@Author(s) - Available online at www.annalsmedres.org
Content of this journal is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.


Aim: In BI-RADS 4A lesions, a malignancy rate of between 2% and 10% has been detected. Many patients avoid biopsy even though biopsy is recommended because of its low malignancy rates. The aim of this study is to investigate the need for biopsy of patients with BI-RADS 4A lesions.
Materials and Methods: 392 patients classified as BI-RADS 4A in our hospital between January 2011 and December 2019 were retrospectively analyzed. Clinical and demographic characteristics of the patients, complaints, physical examination findings, USG (ultrasound), MMG (mammography) and magnetic resonance imaging (MRI) findings, invasive surgical procedure or noninvasive procedure performed, pathology results were analyzed.
Results: The mean age was 44.29 years (range, 15–93 years). The most common complaint was palpable mass (36.5%). While 88.5% of examined pathologies were evaluated as benign lesions, 7.1% were malignant. The rate of malignancy increased with age, and this difference was statistically significant (p = .000). Malignancy increases with lesions size but it was not statistically significant (p = .052). Palpable mass was more common in malignant lesions (55.2%) (p = .014). Comparing the radiological evaluations of BI-RADS 4A lesions with the post-biopsy pathology results, size increase, more than three lobulations, border irregularities, and cystic areas did not make a statistically significant difference in terms of benign, premalignant, and malignant pathologies; however, intraductal localization was observed more frequently in benign and premalignant lesions than in malignant lesions, and this difference was statistically significant (p = .003).
Conclusion: We anticipate that the criteria developed with this study (more than three lobulations, border irregularity, cystic areas, and intraductal locations), applied to a wide range of patients, can be a source for future studies and can be used safely in other clinics. As a result, we strongly recommend biopsy for patients with postmenopausal and palpable masses if the criteria we used for detecting BI-RADS 4A are also present.

Keywords: BI-RADS 4A; breast biopsy; breast cancer

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doi: 10.5455/annalsmedres.2020.02.136   


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Annals of Medical Research is the scientific official journal of the Inonu University Faculty of Medicine. It is published monthly. The essential aim of the Annals of Medical Research is to publish scientifically high quality clinical and experimental research articles on fields of medicine which can contribute to the literature data. In addition, review articles, case reports, editorials, letters to the editors and manuscripts on publication ethics and medical history, which can contribute to the education and practices of physicians and health sector professionals within the scope of the journal’s target audience and which can increase the level of scientific communication between the authors and readers, are included in the scope of the journal.


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