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Formerly Journal of Turgut Ozal Medical Center

  • Annals of Medical Research



    Annals of Medical Research International Monthly Published Medical Journal

  • Annals of Medical Research

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  • Annals of Medical Research
  • Annals of Medical Research
  • Annals of Medical Research
  • Annals of Medical Research

Dear Annals of Medical Research Readers

As of the end of March 2021, I have started to work as Chief Editor at Annals of Medical Research. Our journal is the official publication of Inonu University Medical Faculty and published uninterruptedly for 28 years.  Our Journal, which is online as an open access journal with monthly free access, is being scanned in many national and international indexes (ULAKBIM TR Dizin, Turkish Medline, EBSCO, Google Scholar, etc.). I would like to thank the Editors before me who contributed to this level. Our primary goal is to ensure the maintenance of this good state of the journal and to ensure that it is scanned in prestigious international indexes (Pubmed Central, SCI-Expended, etc.). In order to achieve these goals, it depends on the original research articles that can be cited and the articles published in our Journal to be cited sufficiently in other international journals. The contributions of our readers, reviewers and authors in achieving this goal are of great importance.

I hope to announce the news that we have reached our goals as soon as possible.

MD. Prof. Nevzat Erdil

Editor-in-Chief

Annals of Medical Research

 

Association of adenovirus 36 and gynecomastia development: A case-control study (p.537-41)

Association of adenovirus 36 and gynecomastia development: A case-control study (p.537-41)

Serhat Sirekbasan1, Harika Oyku Dinc2, Ozgur Pilanci3, Melike Keskin2, Eda Altan4, Oguz Cortuk3, Nuri Turan4, Mehmet Velidedeoglu5, Selcuk Koksal6, Suat Saribas2, Sevgi Ergin2, Huseyin Yilmaz4, Bekir Kocazeybek2
1Department of Medical Laboratory Techniques, Cankiri Karatekin University, Eldivan Vocational School of Health Services, Cankiri, Turkey
2Department of Medical Microbiology, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey
3Department of Plastic Reconstructive and Aesthetic Surgery, Bagcilar Research and Training Hospital, Istanbul, Turkey
4Department of Virology, Faculty of Veterinary, Istanbul University-Cerrahpasa, Istanbul, Turkey
5Department of General Surgery, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey
6Department of Public Health, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey
Copyright@Author(s) - Available online at www.annalsmedres.org
Content of this journal is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Abstract

Aim: The interaction of various adipokines secreted from adipose tissue during Adenovirus 36 (Ad-36) infection may cause gynecomastia. In this study, we aimed to evaluate the association between Ad-36 and gynecomastia development by determining DNAs and antibodies of Ad-36, adiponectin, leptin, and IL-6 levels.
Materials and Methods: Patient and control groups were composed of from 33 male adults with gynecomastia and 15 male adults with anatomic disorders without gynecomastia, respectively. Serum neutralization assay (SNA) was used for the determination of Ad-36 antibodies and PCR method was used for the determination of Ad-36 DNA.
Results: No Ad-36 DNA was found in the breast tissue samples. Ad-36 antibody levels were detected in the patient group with gynecomastia higher than the control group (p0.05). Serum leptin and adiponectin levels were detected to be significantly different from each other (p0.05).
Conclusion: In conclusion, a low-grade chronic inflammation may be caused by Ad-36 infections, leading to increased circulating leptin levels. Consequently, leptin may lead to an increase in local or circulating estrogen levels by stimulating the aromatase enzyme in breast tissue and adipose stromal cells.

Keywords: Adenovirus 36; gynecomastia; leptin; serum neutralization assay

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doi: 10.5455/annalsmedres.2020.05.543   

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Annals of Medical Research is the scientific official journal of the Inonu University Faculty of Medicine. It is published monthly. The essential aim of the Annals of Medical Research is to publish scientifically high quality clinical and experimental research articles on fields of medicine which can contribute to the literature data. In addition, review articles, case reports, editorials, letters to the editors and manuscripts on publication ethics and medical history, which can contribute to the education and practices of physicians and health sector professionals within the scope of the journal’s target audience and which can increase the level of scientific communication between the authors and readers, are included in the scope of the journal.

 

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