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  • Annals of Medical Research



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  • Annals of Medical Research

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  • Annals of Medical Research
  • Annals of Medical Research
  • Annals of Medical Research
  • Annals of Medical Research

Dear Annals of Medical Research Readers

As of the end of March 2021, I have started to work as Chief Editor at Annals of Medical Research. Our journal is the official publication of Inonu University Medical Faculty and published uninterruptedly for 28 years.  Our Journal, which is online as an open access journal with monthly free access, is being scanned in many national and international indexes (ULAKBIM TR Dizin, Turkish Medline, EBSCO, Google Scholar, etc.). I would like to thank the Editors before me who contributed to this level. Our primary goal is to ensure the maintenance of this good state of the journal and to ensure that it is scanned in prestigious international indexes (Pubmed Central, SCI-Expended, etc.). In order to achieve these goals, it depends on the original research articles that can be cited and the articles published in our Journal to be cited sufficiently in other international journals. The contributions of our readers, reviewers and authors in achieving this goal are of great importance.

I hope to announce the news that we have reached our goals as soon as possible.

MD. Prof. Nevzat Erdil

Editor-in-Chief

Annals of Medical Research

 

Evaluation of the relationship between corpus callosum and internal capsule and tuber load in patients with tuberous sclerosis complex by diffusion tensor imaging (p.575-8)

Evaluation of the relationship between corpus callosum and internal capsule and tuber load in patients with tuberous sclerosis complex by diffusion tensor imaging (p.575-8)

Dilek Hacer Cesme
Department of Radiology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey
Copyright@Author(s) - Available online at www.annalsmedres.org
Content of this journal is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Abstract

Aim: To determine whether there are Diffusion Tensor Imaging (DTI) changes in the white matter pathways such as corpus callosum and internal capsule in patients with Tuberous sclerosis complex (TSC) and to investigate its relationship with tuber load.
Materials and Methods: Our study included 17 children with TSC and 15 healthy controls. Total tuber load of the brain was calculated. Correlation between tuber load and ADC (Apparent diffusion coefficient) and FA (Fractional anisotropy) values at corpus callosum (CC) and internal capsule were investigated.
Results: When patients with TSC were compared with control, there was a significant difference in ADC and FA values in the corpus callosum and internal capsule. There was a significant difference in FA values between the anterior and posterior limbs of the internal capsule on both sides. The ADC values of CC splenium were positively correlated with the total cerebral tuber load. Also, The FA values obtained from CC splenium were negatively correlated with the tuber load of the right cerebral hemisphere.
Conclusion: Relationships between corpus callosum and internal capsule ADC and FA changes and tuber load show that microstructural damage develops in the white matter pathways. DTI parameters can be used as a more sensitive biomarker in the evaluation of the abnormal structure of white matter in patients with TSC. More comprehensive studies are needed to more clearly demonstrate the relationship between DTI properties of white matter and tuber load in TSC patients.

Keywords: Corpus callosum; diffusion tensor imaging; tuber load; tuberous sclerosis complex

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doi: 10.5455/annalsmedres.2020.06.580 

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Annals of Medical Research is the scientific official journal of the Inonu University Faculty of Medicine. It is published monthly. The essential aim of the Annals of Medical Research is to publish scientifically high quality clinical and experimental research articles on fields of medicine which can contribute to the literature data. In addition, review articles, case reports, editorials, letters to the editors and manuscripts on publication ethics and medical history, which can contribute to the education and practices of physicians and health sector professionals within the scope of the journal’s target audience and which can increase the level of scientific communication between the authors and readers, are included in the scope of the journal.

 

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