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Formerly Journal of Turgut Ozal Medical Center

  • Annals of Medical Research



    Annals of Medical Research International Monthly Published Medical Journal

  • Annals of Medical Research

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  • Annals of Medical Research


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  • Annals of Medical Research
  • Annals of Medical Research
  • Annals of Medical Research
  • Annals of Medical Research

Dear Annals of Medical Research Readers

As of the end of March 2021, I have started to work as Chief Editor at Annals of Medical Research. Our journal is the official publication of Inonu University Medical Faculty and published uninterruptedly for 28 years.  Our Journal, which is online as an open access journal with monthly free access, is being scanned in many national and international indexes (ULAKBIM TR Dizin, Turkish Medline, EBSCO, Google Scholar, etc.). I would like to thank the Editors before me who contributed to this level. Our primary goal is to ensure the maintenance of this good state of the journal and to ensure that it is scanned in prestigious international indexes (Pubmed Central, SCI-Expended, etc.). In order to achieve these goals, it depends on the original research articles that can be cited and the articles published in our Journal to be cited sufficiently in other international journals. The contributions of our readers, reviewers and authors in achieving this goal are of great importance.

I hope to announce the news that we have reached our goals as soon as possible.

MD. Prof. Nevzat Erdil

Editor-in-Chief

Annals of Medical Research

 

Does hyperthermic intraperitoneal chemotherapy influence the rate of infective complications and change the pattern of infectious agents in patients undergoing cytoreductive surgery for peritoneal carcinomatosis? (p.586-92)

Does hyperthermic intraperitoneal chemotherapy influence the rate of infective complications and change the pattern of infectious agents in patients undergoing cytoreductive surgery for peritoneal carcinomatosis? (p.586-92)

Umit Mercan1, Ogun Ersen1, Cemil Yuksel2, Ali Ekrem Unal1
1Department of Surgical Oncology, Faculty of Medicine, Anakara University, Ankara, Turkey
2Ministry of Health Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Ankara, Turkey
Copyright@Author(s) - Available online at www.annalsmedres.org
Content of this journal is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Abstract

Aim: When CRS, in which complex surgical procedures are applied combined with HIPEC in which high dose cytotoxic agents are applied, many serious postoperative complications, especially infection-related complications, may develop in the patient group with peritoneal carcinomatosis whose general condition is impaired. In this study, it was aimed to investigate the effect of HIPEC application after SRC on infection rates and microbial agent spectrum alone.
Materials and Methods: Between January 2012 and January 2020, one thousand six hundreds forty eight patients diagnosed with peritoneal carcinomatosis were scanned from hospital database and two hundred thirty-five eligible patients were included in the study. Demographic and clinical data, perioperative results and culture results were analyzed by grouping the patients as HIPEC and non-HIPEC.
Results : It has been found that the incidence of surgical site infections was significantly higher in HIPEC group. (23.6%vs11.5%p=0.011).When the culture results were analyzed. The number of patients with E.coli (13.7% vs 5.7% p = 0.001), Klebsiella pneumoniae (9.9% vs 2.8% p = 0.001) and Pseudomonas aeruginosa (2.2% vs 0.9% p = 0.034) growth was significantly higher in the HIPEC group.
Conclusions: It has been found that HIPEC application not only increases the infection rates but also expands the potential pathogen spectrum. Prediction of possible pathogens responsible for postoperative infections may affect the choice of prophylactic and ultimate treatment and so the risk of developing morbidity and mortality which may result from a possible septic progression, can be minimized with an effective antimicrobial therapy.

Keywords: Carcinomatosis; cytoreductive surgery; infections

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doi: 10.5455/annalsmedres.2020.09.941 

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Annals of Medical Research is the scientific official journal of the Inonu University Faculty of Medicine. It is published monthly. The essential aim of the Annals of Medical Research is to publish scientifically high quality clinical and experimental research articles on fields of medicine which can contribute to the literature data. In addition, review articles, case reports, editorials, letters to the editors and manuscripts on publication ethics and medical history, which can contribute to the education and practices of physicians and health sector professionals within the scope of the journal’s target audience and which can increase the level of scientific communication between the authors and readers, are included in the scope of the journal.

 

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