2Department of General Surgery, KTO Karatay University, Faculty of Medicine, Konya, Turkey
3Department of General Surgery, Medova Hospital, Konya, Turkey
4Department of Gynecology and Obstetrics, Konya Medicana Hospital, Konya, Turkey
5Department of General Surgery, Usak University, Faculty of Medicine, Usak, Turkey
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Aim: The objective of this study is to evaluate the effectiveness of ursodeoxycholic acid (UDCA) for the treatment of symptomatic pregnant women with gall bladder stones and/or sludge.
Material and Methods: Gynecology and obstetrics clinic patients who were symptomatic with gallbladder stones and/or microlithiasis were included in the study. Group 1 consisted of cases with conservative treatment and group 2 consisted of cases with UDCA treatment. After treatment, the groups were compared for symptomatic and radiological relief and hospitalization.
Results: For group 2, the mean treatment time with UDCA was 7.6 weeks. After treatment, a full cure was achieved in 28% of cases and symptomatic relief was achieved in 36% of cases. In group one; there was response to treatment in only 12% of cases. In the UDCA group, none of the patients needed hospitalization; however, in the conservative treatment group, five cases needed hospitalization.
Conclusion: UDCA is effective for the treatment of symptomatic gall bladder disease in pregnancy. It both relieves symptoms and decreases the need for hospitalization.
Keywords: Gall bladder; gallstone; pregnancy; sludge; ursodeoxycholic acid