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Formerly Journal of Turgut Ozal Medical Center - ISSN 1300-1744

  • Annals of Medical Research



    Annals of Medical Research International Monthly Published Medical Journal

  • Annals of Medical Research

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  • Annals of Medical Research


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  • Annals of Medical Research


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  • Annals of Medical Research
  • Annals of Medical Research
  • Annals of Medical Research
  • Annals of Medical Research

Dear readers,

Our journal is the official publication of Inonu University Medical Faculty and published uninterruptedly for 25 years. It was first published as the name of Inonu University Medical Journal and later as Journal of Turgut Ozal Medical Center. During its publication period, the journal accepted Turkish or English articles for publication.

Abstracting in an international index is just a paramount objective in the 25th year of the journal. Because of this goal, it was necessary to make a decision both in terms of journal name and publication language. It was important in this respect that the name of a general medical journal should be related to medicine again and it should be in English. For these reasons, the name of the journal was switched to Annals of Medical Research and its publication language is changed to in English. The logo of the journal was chosen as an apricot, which is the symbol of our city Malatya, the world capital of apricot. I hope the journal succeeds with its new name. Annals of Medical Research is published monthly.

Editor-in-Chief

 

The role of procalcitonin and C-reactive protein in predicting candidemia in reanimation intensive care unit and burn unit patients (p.62-6)

The role of procalcitonin and C-reactive protein in predicting candidemia in reanimation intensive care unit and burn unit patients (p.62-6)

Sibel Altunisik Toplu1, Yasemin Ersoy1, Yucel Duman2, Emine Nalan Parmaksiz3, Ayse Belin Ozer4, Cemal Firat5
1Department of Infectious Diseases, Faculty of Medicine, Inonu University, Malatya, Turkey
2Department of Clinical Microbiology, Faculty of Medicine, Inonu University, Malatya, Turkey
3Infection Control Committee, Turgut Ozal Medical Center, Malatya-Turkey
4Department of Anesthesiology and Reanimation, Faculty of Medicine, Inonu University, Malatya, Turkey
5Department of Plastic Surgery and Reconstruction, Faculty of Medicine, Inonu University, Malatya, Turkey
Copyright@Author(s) - Available online at www.annalsmedres.org
Content of this journal is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Abstract

Aim: Predicting the diagnosis of candidemia remains a challenge for physicians. It is difficult to distinguish candidemia from other potential conditions, especially in patients under intensive care. Although blood culture is the gold standard in diagnosis, there is continued search for other markers that may be used for early prediction.
This study intended to assess if procalcitonin (PCT) and C-reactive protein (CRP) may be able to guide the course of Candidemia.
Materials and Methods: The study included patients over the age of 18 admitted to the Reanimation Intensive Care Unit and Burn Unit between June 2018 and June 2019 whose blood cultures exhibited growth of Candida species (spp.). Moreover, the patients’ blood cultures were also tested for Gram negative and Grow positive bacterial growth that may accompany Candida species (spp.). For all patients, we recorded the PCT and CRP values three times.
Results: This study examined sixty-six patients exhibiting growth of Candida spp. in their blood cultures; 42 (64%) cases had no accompanying bacterial growth in their culture (Group 1). In addition to the growth of Candida spp., the blood cultures showed that 16 patients also had Gram-negative bacteremia (Group 2), and eight patients had Gram-positive bacteremia (Group 3). When a cut-off value of 0.5 ng/mL was considered for all candidemia patients, the first assessments did not show a statistically significant high value (p=0.053). However, when evaluated with bacteremia, the first PCT results were higher in patients with Gram-negative bacteremia. PCT and CRP changes over time were statistically significant based on two-way repeated measures comparisons (p0.05). There was a positive correlation between PCT values and mortality (p0.01).
Conclusion: We believe that the decrease in PCT and CRP values are helpful while clinically monitoring patients with candidemia.

Keywords: Candidemia; C-reactive protein; procalcitonin

 

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doi:10.5455/annalsmedres.2020.12.1158

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Annals of Medical Research is the scientific official journal of the Inonu University Faculty of Medicine. It is published monthly. The essential aim of the Annals of Medical Research is to publish scientifically high quality clinical and experimental research articles on fields of medicine which can contribute to the literature data. In addition, review articles, case reports, editorials, letters to the editors and manuscripts on publication ethics and medical history, which can contribute to the education and practices of physicians and health sector professionals within the scope of the journal’s target audience and which can increase the level of scientific communication between the authors and readers, are included in the scope of the journal.

 

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