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Formerly Journal of Turgut Ozal Medical Center - ISSN 1300-1744

  • Annals of Medical Research

    Annals of Medical Research International Monthly Published Medical Journal

  • Annals of Medical Research

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  • Annals of Medical Research

    Annals of Medical Research indexed in TÜBİTAK/ULAKBİM Tıp Veri Tabanı

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  • Annals of Medical Research
  • Annals of Medical Research
  • Annals of Medical Research
  • Annals of Medical Research

Dear readers,

Our journal is the official publication of Inonu University Medical Faculty and published uninterruptedly for 25 years. It was first published as the name of Inonu University Medical Journal and later as Journal of Turgut Ozal Medical Center. During its publication period, the journal accepted Turkish or English articles for publication.

Abstracting in an international index is just a paramount objective in the 25th year of the journal. Because of this goal, it was necessary to make a decision both in terms of journal name and publication language. It was important in this respect that the name of a general medical journal should be related to medicine again and it should be in English. For these reasons, the name of the journal was switched to Annals of Medical Research and its publication language is changed to in English. The logo of the journal was chosen as an apricot, which is the symbol of our city Malatya, the world capital of apricot. I hope the journal succeeds with its new name. Annals of Medical Research is published monthly.



Effects of diosmin-hesperidin and low pressure compression stocking combination in superficial venous insufficiency (p.132-5)

Effects of diosmin-hesperidin and low pressure compression stocking combination in superficial venous insufficiency (p.132-5)

Metin Onur Beyaz, Emin Can Ata
Department of Cardiothoracic Surgery, Faculty of Medicine, Istanbul Medipol University, Medipol Mega University Hospital, Istanbul, Turkey
Copyright@Author(s) - Available online at www.annalsmedres.org
Content of this journal is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.


Aim: The main aim of the study is to investigate the efficacy and patient tolerance of Daflon 1000mg/day and low-pressure compression stocking combination in the treatment of superficial venous insufficiency.
Materials and Methods: This prospective study included 112 patients diagnosed with superficial venous insufficiency and reflux in saphenofemoral junction during March 2018 and 2019 at our center. All the patients received 1000 mg micronized purified flavonoid fractions containing 90% diosmin-10% hesperidin and low-pressure venous compression stockings (15-20 mmHg) throughout the study. Patients superficial, perforator, and deep venous systems were evaluated by Doppler US at the beginning and average of 5.3 ± 3.7 months after treatment.
Results: A total of 99 (88.4%) patients out of 112 eligible patients completed the investigation. The mean age was 41±12.6, the female was 66 (58.9%), the mean follow-up was 5.3±3.7 months. Pre-treatment and post-treatment diameters of SFJ were 6.27±2.9 and 5.68±1.8 mm, respectively, this was statistically significant (P=0.033). All of the patients have SFJ reflux initially, after the treatment, patients with SFJ reflux were decreased to 44 (44.4%), this was also statistically significant (P0.001, OR:0.004, 95% CI: 0.0002-0.07). We also found significant improvement in grade III and grade IV reflux (P0.05) after treatment. The symptomatic patients decreased from 63 to 16 after treatment, this was statistically severely significant (P0.001, OR:0.11, 95% CI: 0.056-0.216). During the follow-up period, 6 (5.4%) patients were worsened and underwent surgical intervention, this was not statistically significant (P=0.076).
Conclusion: Daflon 1000mg/day with a combination of low- pressure CS well tolerates by venous insufficiency patients. Six months of continuous application may reduce the reflux of SFJ and VSM, and causes marked symptomatic relief.

Keywords: Chronic venous insufficiency; diosmin-hesperidin combination; edema




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Annals of Medical Research is the scientific official journal of the Inonu University Faculty of Medicine. It is published monthly. The essential aim of the Annals of Medical Research is to publish scientifically high quality clinical and experimental research articles on fields of medicine which can contribute to the literature data. In addition, review articles, case reports, editorials, letters to the editors and manuscripts on publication ethics and medical history, which can contribute to the education and practices of physicians and health sector professionals within the scope of the journal’s target audience and which can increase the level of scientific communication between the authors and readers, are included in the scope of the journal.


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