• E-ISSN 2636-7688

Formerly Journal of Turgut Ozal Medical Center

  • Annals of Medical Research

    Annals of Medical Research International Monthly Published Medical Journal

  • Annals of Medical Research

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  • Annals of Medical Research

    Annals of Medical Research indexed in TÜBİTAK/ULAKBİM Tıp Veri Tabanı

  • Annals of Medical Research

    Annals of Medical Research indexed in

  • Annals of Medical Research
  • Annals of Medical Research
  • Annals of Medical Research
  • Annals of Medical Research

Dear Annals of Medical Research Readers

As of the end of March 2021, I have started to work as Chief Editor at Annals of Medical Research. Our journal is the official publication of Inonu University Medical Faculty and published uninterruptedly for 28 years.  Our Journal, which is online as an open access journal with monthly free access, is being scanned in many national and international indexes (ULAKBIM TR Dizin, Turkish Medline, EBSCO, Google Scholar, etc.). I would like to thank the Editors before me who contributed to this level. Our primary goal is to ensure the maintenance of this good state of the journal and to ensure that it is scanned in prestigious international indexes (Pubmed Central, SCI-Expended, etc.). In order to achieve these goals, it depends on the original research articles that can be cited and the articles published in our Journal to be cited sufficiently in other international journals. The contributions of our readers, reviewers and authors in achieving this goal are of great importance.

I hope to announce the news that we have reached our goals as soon as possible.

MD. Prof. Nevzat Erdil


Annals of Medical Research


Improved treatment of recurrent aphthous stomatitis with sodium pentaborate pentahydrate (NaB) (p.210-4)

Improved treatment of recurrent aphthous stomatitis with sodium pentaborate pentahydrate (NaB) (p.210-4)

Ayse Sezim Safak1, Fikrettin Sahin2
1Department of Audiometry, Faculty of Medicine, Istanbul Yeniyuzyıi University, Istanbul,Turkey
2Department of Genetics and Bioengineering, Faculty of Engineering and Architecture, Yeditepe University, Istanbul, Turkey
Copyright@Author(s) - Available online at www.annalsmedres.org
Content of this journal is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.



Aim: Chlorhexidine (CHX) and benzydamine hydrochloride (B-HCl) combination treatment (Kloroben™ spray) was compared with sodium pentaborate pentahydrate (NaB, also called boron) treatment with regard to their effects in the recovery of recurrent aphthous stomatitis (RAS).
Materials and Methods: We assessed the treatment results by evaluating ulcer radius and VAS results. Seventy-one patients with clinically diagnosed minor RAS were selected for the study based on inclusion and exclusion criteria. Group 1 was treated with a 3% solution of NaB and group 2 was treated with Kloroben spray (45 mg benzydamine HCl and 36 mg chlorhexidine gluconate) for 1 week.
Results: After the treatments, there were statistically significant decreases in VAS scores in both Group 1 (p0.001) and Group 2 (p0.001). We found that the decrease in VAS score was greater in Group 1 than in Group 2 (p0.001). Similarly, there were statistically significant decreases in ulcer diameters for both groups. The ulcer diameter reduction was also greater in Group 1 than Group 2 (p0.001).
Conclusions: When the specifications of NaB and studies that report its effects are considered, it may be concluded that NaB works well in the healing process of oral aphthae. Our findings show that NaB is better than CHX for the treatment of RAS, which is demonstrated by greater reduction of ulcer diameter and pain score in the NaB group.

Keywords: Chlorhexidine; recurrent aphthous stomatitis; sodium pentaborate pentahydrate




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Annals of Medical Research is the scientific official journal of the Inonu University Faculty of Medicine. It is published monthly. The essential aim of the Annals of Medical Research is to publish scientifically high quality clinical and experimental research articles on fields of medicine which can contribute to the literature data. In addition, review articles, case reports, editorials, letters to the editors and manuscripts on publication ethics and medical history, which can contribute to the education and practices of physicians and health sector professionals within the scope of the journal’s target audience and which can increase the level of scientific communication between the authors and readers, are included in the scope of the journal.


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