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Formerly Journal of Turgut Ozal Medical Center

  • Annals of Medical Research



    Annals of Medical Research International Monthly Published Medical Journal

  • Annals of Medical Research

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  • Annals of Medical Research


    Annals of Medical Research indexed in TÜBİTAK/ULAKBİM Tıp Veri Tabanı

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  • Annals of Medical Research
  • Annals of Medical Research
  • Annals of Medical Research
  • Annals of Medical Research

Dear Annals of Medical Research Readers

As of the end of March 2021, I have started to work as Chief Editor at Annals of Medical Research. Our journal is the official publication of Inonu University Medical Faculty and published uninterruptedly for 28 years.  Our Journal, which is online as an open access journal with monthly free access, is being scanned in many national and international indexes (ULAKBIM TR Dizin, Turkish Medline, EBSCO, Google Scholar, etc.). I would like to thank the Editors before me who contributed to this level. Our primary goal is to ensure the maintenance of this good state of the journal and to ensure that it is scanned in prestigious international indexes (Pubmed Central, SCI-Expended, etc.). In order to achieve these goals, it depends on the original research articles that can be cited and the articles published in our Journal to be cited sufficiently in other international journals. The contributions of our readers, reviewers and authors in achieving this goal are of great importance.

I hope to announce the news that we have reached our goals as soon as possible.

MD. Prof. Nevzat Erdil

Editor-in-Chief

Annals of Medical Research

 

Surgical and clinical management of neutropenic enterocolitis seen in hematological and solid organ malignancies (p.215-20)

Surgical and clinical management of neutropenic enterocolitis seen in hematological and solid organ malignancies (p.215-20)

Server Sezgin Uludag1, Emre Tunc1, Ahmet Necati Sanli1, Tugrul Elverdi2, Mehmet Velidedeoglu1, Osman Simsek1, Salih Pekmezci1, Abdullah Kagan Zengin1
1Department of General Surgery, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey
2Department of Hematology, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey
Copyright@Author(s) - Available online at www.annalsmedres.org
Content of this journal is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Abstract

Aim: Ileocecal syndrome also called typhilite; It is defined as inflammation of the cecum and surrounding tissues seen in immunosuppressed patients. Typhilite is a serious disease in the ileum, cecum, and ascending colon with segmental inflammation and necrosis due to ulceration. The disease has difficulties in its diagnosis, treatment, and surgery. We aimed to examine the difficulties in diagnosis and treatment in this disease, which has high morbidity and mortality.
Materials and Methods: Patients who have hematological or solid organ malignancies, diagnosed with neutropenic enterocolitis between January 2014 and December 2019 were included in the study. The demographic information, malignancies, chemotherapy treatments, follow-ups, clinical symptoms, laboratory, and radiology findings of the patients were examined.
Results: A total of 7 patients were identified between the dates indicated, 4 were male and 3 were female. The mean age was 58.5. Six of these patients had hematological and one had solid organ malignancy. All patients had the typical fever (above 38), non-migratory abdominal pain localized to the right lower quadrant, and neutropenia (0.5 x10³/mm³). The mean value of Neutrophil at the time symptoms began was 0.15x10³/mm³. Intestinal wall thickening, mesenteric inflammation findings were present in all patients, and pneumocystis intestinalis and perforation were detected in one patient. As presented patients, with increased experience, most of the patients were demonstrated to be treated with consisting of aggressive fluid resuscitation, correction of electrolyte imbalance, bowel rest, and wide-spectrum antibiotics. Two patients died due to severe fungal infection.
Conclusion: It is hard to make a common algorithm for diagnosis for NE because NE is a pre-diagnosis. Due to its clinical heterogeneity, treatment modality ranges from surgical treatment to conservative approach. As a result of higher success rates of conservative management, supportive care, and close follow up have replaced surgery in the treatment of this disease.

Keywords: Chemotherapy; ileocecal syndrome; neutropenia; neutropenic enterocolitis; surgery; typhilite

 

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doi:10.5455/annalsmedres.2020.05.507

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Annals of Medical Research is the scientific official journal of the Inonu University Faculty of Medicine. It is published monthly. The essential aim of the Annals of Medical Research is to publish scientifically high quality clinical and experimental research articles on fields of medicine which can contribute to the literature data. In addition, review articles, case reports, editorials, letters to the editors and manuscripts on publication ethics and medical history, which can contribute to the education and practices of physicians and health sector professionals within the scope of the journal’s target audience and which can increase the level of scientific communication between the authors and readers, are included in the scope of the journal.

 

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