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Formerly Journal of Turgut Ozal Medical Center - ISSN 1300-1744

  • Annals of Medical Research



    Annals of Medical Research International Monthly Published Medical Journal

  • Annals of Medical Research

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  • Annals of Medical Research
  • Annals of Medical Research
  • Annals of Medical Research
  • Annals of Medical Research

Dear readers,

Our journal is the official publication of Inonu University Medical Faculty and published uninterruptedly for 25 years. It was first published as the name of Inonu University Medical Journal and later as Journal of Turgut Ozal Medical Center. During its publication period, the journal accepted Turkish or English articles for publication.

Abstracting in an international index is just a paramount objective in the 25th year of the journal. Because of this goal, it was necessary to make a decision both in terms of journal name and publication language. It was important in this respect that the name of a general medical journal should be related to medicine again and it should be in English. For these reasons, the name of the journal was switched to Annals of Medical Research and its publication language is changed to in English. The logo of the journal was chosen as an apricot, which is the symbol of our city Malatya, the world capital of apricot. I hope the journal succeeds with its new name. Annals of Medical Research is published monthly.

Editor-in-Chief

 

Dynamic thiol-disulfide balance in patients with chronic sinusitis with and without nasal polyposis (p.3076-80)

Dynamic thiol-disulfide balance in patients with chronic sinusitis with and without nasal polyposis (p.3076-80)

Ergun Sevil1, Fatih Gul2, Tolga Oguzhan3, Sami Bercin2, Salim Neselioglu4, Cemile Bicer4
1Department of Otorhinolaryngology, Trabzon Kanuni Training and Research Hospital, Trabzon, Turkey
2Department of Otorhinolaryngology, Faculty of Medicine, Yildirim Beyazit University, Ankara, Turkey
3Department of Otorhinolaryngology, Medical Park Hospital, Istanbul, Turkey
4Department of Biochemistry, Faculty of Medicine, Yildirim Beyazit University, Ankara, Turkey
Copyright@Author(s) - Available online at www.annalsmedres.org
Content of this journal is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Abstract

Aim: Reactive oxygen species (ROS) have a crucial role in the pathogenesis of chronic rhinosinusitis (CRS). The current study investigates a novel oxidative stress marker (thiol (SH)/disulfide (SS) homeostasis) in patients with CRS with and without nasal polyposis (NPs).
Materials and Methods: A total of 167 subjects, including 94 patients with CRS and 73 healthy controls, were included in the study. The patients were subdivided into two groups those with CRS with NP and those with CRS without NP. Comparisons were made between the groups in respect of serum native SH, total thiol (TT), and SS levels and the SS/SH and SS/TT ratios.
Results: There was no significant difference in TT between the CRS with the NP group and the CRS without the NP group (p> 0.05). There was a significant difference (p 0.05) between the CRS without the NP group and the control group in %SH/TT, %SS/TT, %SS/SH, SS, and SH. A significant difference (p 0.05) was found between the CRS with the NP group and the control group in %SH/TT, %SS/TT, %SS/SH, SS and SH values.
Conclusion: Dynamic SH/SS homeostasis shifts towards SS formation as a result of SH oxidation in patients with CRS.

Keywords: Chronic sinusitis; nasal polyp; oxidative stress; sulfhydryl compounds

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doi:10.5455/annalsmedres.2020.04.313

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Annals of Medical Research is the scientific official journal of the Inonu University Faculty of Medicine. It is published monthly. The essential aim of the Annals of Medical Research is to publish scientifically high quality clinical and experimental research articles on fields of medicine which can contribute to the literature data. In addition, review articles, case reports, editorials, letters to the editors and manuscripts on publication ethics and medical history, which can contribute to the education and practices of physicians and health sector professionals within the scope of the journal’s target audience and which can increase the level of scientific communication between the authors and readers, are included in the scope of the journal.

 

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