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Formerly Journal of Turgut Ozal Medical Center - ISSN 1300-1744

  • Annals of Medical Research



    Annals of Medical Research International Monthly Published Medical Journal

  • Annals of Medical Research

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  • Annals of Medical Research


    Annals of Medical Research indexed in TÜBİTAK/ULAKBİM Tıp Veri Tabanı

  • Annals of Medical Research


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  • Annals of Medical Research
  • Annals of Medical Research
  • Annals of Medical Research
  • Annals of Medical Research

Dear readers,

Our journal is the official publication of Inonu University Medical Faculty and published uninterruptedly for 25 years. It was first published as the name of Inonu University Medical Journal and later as Journal of Turgut Ozal Medical Center. During its publication period, the journal accepted Turkish or English articles for publication.

Abstracting in an international index is just a paramount objective in the 25th year of the journal. Because of this goal, it was necessary to make a decision both in terms of journal name and publication language. It was important in this respect that the name of a general medical journal should be related to medicine again and it should be in English. For these reasons, the name of the journal was switched to Annals of Medical Research and its publication language is changed to in English. The logo of the journal was chosen as an apricot, which is the symbol of our city Malatya, the world capital of apricot. I hope the journal succeeds with its new name. Annals of Medical Research is published monthly.

Editor-in-Chief

 

Evaluation of the relationship between MAOA-uVNTR gene polymorphism and impulsivity, anger, temperament and personality traits in healthy male subjects (p.3136-42)

Evaluation of the relationship between MAOA-uVNTR gene polymorphism and impulsivity, anger, temperament and personality traits in healthy male subjects (p.3136-42)

Hasan Kaya1, Ozlem Bolat Kaya2, Aybeniz Civan Kahve1, Nesrin Dilbaz3
1Department of Psychiatry, University of Health Sciences, Ankara City Hospital, Ankara, Turkey
2Department of Psychiatry, Yenimahalle Training and Research Hospital, Ankara, Turkey
3Department of Psychiatry, Faculty of Medicine, Uskudar University, Istanbul, Turkey

Copyright@Author(s) - Available online at www.annalsmedres.org
Content of this journal is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Abstract

Aim: Serotonergic activity in the central nervous system negatively correlates with personality traits associated with aggression, impulsivity and anger. MAOA is involved in the catabolism of serotonin and norepinephrine, so the gene encoding MAOA is a candidate gene for aggression-related behavior. It is thought that MAOA genetic variants affect the MAOA activity at different degrees, leading to behavioral changes as a result of a decrease in enzyme activity. The aim of this study is investigating the possible relationship between the MAOA-uVNTR polymorphism genotypes and aggression, anger, impulsivity, temperament-character traits in healthy male subjects.
Materials and Methods: 101 Turkish healthy male subjects were included in the study. The participants were given scales to evaluate impulsivity, temperament and character traits, anger and aggression levels. MAOA-uVNTR polymorphism was examined with a sample taken from peripheral blood.
Results: A total of 101 people, 33.6% had low-activity allele and 66.4% had high-activity allele of MAOA gene. There was no significant relationship between the temperament-character traits of the participants and MAOA-uVNTR polymorphism. Impulsivity scales were higher in the low-activity allele group, which was statistically significant in terms of motor impulsivity (p = 0.007), non-planning impulsivity (p = 0.031) and total scores (p = 0.029).
Conclusion: The low-activity allele of MAOA gene may be a marker for impulsivity. This requires both repetitive studies with healthy controls in the Turkish population and studies in different cultures.

Keywords: Character traits; impulsivity; MAOA polymorphism; MAOA-uVNTR; temperament

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doi:10.5455/annalsmedres.2020.06.674

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Annals of Medical Research is the scientific official journal of the Inonu University Faculty of Medicine. It is published monthly. The essential aim of the Annals of Medical Research is to publish scientifically high quality clinical and experimental research articles on fields of medicine which can contribute to the literature data. In addition, review articles, case reports, editorials, letters to the editors and manuscripts on publication ethics and medical history, which can contribute to the education and practices of physicians and health sector professionals within the scope of the journal’s target audience and which can increase the level of scientific communication between the authors and readers, are included in the scope of the journal.

 

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