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Formerly Journal of Turgut Ozal Medical Center - ISSN 1300-1744

  • Annals of Medical Research



    Annals of Medical Research International Monthly Published Medical Journal

  • Annals of Medical Research

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  • Annals of Medical Research


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  • Annals of Medical Research


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  • Annals of Medical Research
  • Annals of Medical Research
  • Annals of Medical Research
  • Annals of Medical Research

Dear readers,

Our journal is the official publication of Inonu University Medical Faculty and published uninterruptedly for 25 years. It was first published as the name of Inonu University Medical Journal and later as Journal of Turgut Ozal Medical Center. During its publication period, the journal accepted Turkish or English articles for publication.

Abstracting in an international index is just a paramount objective in the 25th year of the journal. Because of this goal, it was necessary to make a decision both in terms of journal name and publication language. It was important in this respect that the name of a general medical journal should be related to medicine again and it should be in English. For these reasons, the name of the journal was switched to Annals of Medical Research and its publication language is changed to in English. The logo of the journal was chosen as an apricot, which is the symbol of our city Malatya, the world capital of apricot. I hope the journal succeeds with its new name. Annals of Medical Research is published monthly.

Editor-in-Chief

 

miRNA expression profile in Behcet patients using colchicine (p.3159-65)

miRNA expression profile in Behcet patients using colchicine (p.3159-65)

Nilnur Eyerci1, Eda Balkan2, Sadullah Keles3, Necmettin Akdeniz1
1Department of Medical Biology, Faculty of Medicine, Kafkas University, Kars, Turkey
2Department of Medical Biology, Faculty of Medicine, Ataturk University, Erzurum, Turkey
3Department of Dermatology, Faculty of Medicine, Medeniyet University, Istanbul, Turkey
Copyright@Author(s) - Available online at www.annalsmedres.org
Content of this journal is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Abstract

Aim: Behcet’s disease (BD) is a multi-systemic disorder which shows inflammatory vasculitis characteristic with recurrent oral aphthae, eye lesions, and genital ulceration. MicroRNA’s (miRNAs) are small non-coding RNA molecules that play an important role in the regulation of various biological processes. We aimed to determine miRNAs that are thought to be associated with inflammatory processes in BD patients using colchicine in the active period.
Materials and Methods: We enrolled 24 patients with BD receiving colchicine treatment and a control group comprising 30 healthy unrelated individuals. We studied with a panel where 377 miRNAs were included in the assay.
Results: miR-20a, miR-34a, miR-197, U6snRNA, miR-205, miR-222, miR-296, miR-302a, miR-302c, and miR-372 were observed up-regulated in BD. miR-518b, miR-874 were found down-regulated within the patients. These miRNAs are known to play a role in cancer-related pathways.
Conclusion: In patients treated with colchicine, the change in the expression of these miRNA may give an idea of the effect on the progression of the disease. However, patients in the active period also require further studies to fully understand the role and mechanism of action of the drug.

Keywords: Behcet disease; colchicine; microRNA

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doi:10.5455/annalsmedres.2020.04.377

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Annals of Medical Research is the scientific official journal of the Inonu University Faculty of Medicine. It is published monthly. The essential aim of the Annals of Medical Research is to publish scientifically high quality clinical and experimental research articles on fields of medicine which can contribute to the literature data. In addition, review articles, case reports, editorials, letters to the editors and manuscripts on publication ethics and medical history, which can contribute to the education and practices of physicians and health sector professionals within the scope of the journal’s target audience and which can increase the level of scientific communication between the authors and readers, are included in the scope of the journal.

 

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