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Formerly Journal of Turgut Ozal Medical Center - ISSN 1300-1744

  • Annals of Medical Research



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  • Annals of Medical Research

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  • Annals of Medical Research
  • Annals of Medical Research
  • Annals of Medical Research
  • Annals of Medical Research

Dear readers,

Our journal is the official publication of Inonu University Medical Faculty and published uninterruptedly for 25 years. It was first published as the name of Inonu University Medical Journal and later as Journal of Turgut Ozal Medical Center. During its publication period, the journal accepted Turkish or English articles for publication.

Abstracting in an international index is just a paramount objective in the 25th year of the journal. Because of this goal, it was necessary to make a decision both in terms of journal name and publication language. It was important in this respect that the name of a general medical journal should be related to medicine again and it should be in English. For these reasons, the name of the journal was switched to Annals of Medical Research and its publication language is changed to in English. The logo of the journal was chosen as an apricot, which is the symbol of our city Malatya, the world capital of apricot. I hope the journal succeeds with its new name. Annals of Medical Research is published monthly.

Editor-in-Chief

 

Vitamin E plays a protective role while acrylamide administration disrupted the placenta structure in pregnancy: An experimental study (p.3217-21)

Vitamin E plays a protective role while acrylamide administration disrupted the placenta structure in pregnancy: An experimental study (p.3217-21)

Zeynep Erdemli, Mehmet Erman Erdemli
Inonu University Faculty of Medicine, Department of Medical Biochemistry, Malatya Turkey
Copyright@Author(s) - Available online at www.annalsmedres.org
Content of this journal is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Abstract

Aim: The present study aimed to investigate possible variations in the placental tissues of rats upon acrylamide (AA) and vitamin E (Vit E) applications between the 0th and 20th days of pregnancy.
Materials and Methods: Pregnant rats were divided into control, corn oil, AA, Vit E, AA + Vit E groups. At the end of the experimental period, the abdominal tissue of pregnant rats that were anesthetized with xylazine-ketamine was incised, and the placental tissues that connect the mother and the fetus were removed. Biochemical analyses were conducted based on the malondialdehyde (MDA), reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), protein, total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI) levels in placental tissues.
Results: It was observed that there were no differences between the control and corn oil groups. It was determined that AA administration increased MDA, TOS and OSI levels and decreased SOD, CAT, TAS, and GSH levels when compared to all other groups. Vit E administration increased GSH, TAS, SOD and CAT levels when compared to all other groups. In the AA + Vit E group, it was observed oxidative stress parameters approached control group levels.
Conclusion: Administration of 10 mg/kg/bw AA led to placental oxidative stress in pregnant rats. This action induced by AA was not only through the increase in MDA, TOS and OSI levels, but also through the reduction of GSH, SOD, CAT, and TAS levels, leading to the deterioration of the oxidant-antioxidant balance. Administration of 100 mg/kg/bw Vit E increased antioxidant capacity in placental tissue. To minimize AA-induced toxicity exposure, we recommend the consumption of sufficient Vit E throughout life not only during pregnancy.

Keywords: Placenta; acrylamide; vitamin E; pregnancy; oxidative stress; rat

 

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doi:10.5455/annalsmedres.2020.04.299

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Annals of Medical Research is the scientific official journal of the Inonu University Faculty of Medicine. It is published monthly. The essential aim of the Annals of Medical Research is to publish scientifically high quality clinical and experimental research articles on fields of medicine which can contribute to the literature data. In addition, review articles, case reports, editorials, letters to the editors and manuscripts on publication ethics and medical history, which can contribute to the education and practices of physicians and health sector professionals within the scope of the journal’s target audience and which can increase the level of scientific communication between the authors and readers, are included in the scope of the journal.

 

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