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Formerly Journal of Turgut Ozal Medical Center - ISSN 1300-1744

  • Annals of Medical Research



    Annals of Medical Research International Monthly Published Medical Journal

  • Annals of Medical Research

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  • Annals of Medical Research


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  • Annals of Medical Research
  • Annals of Medical Research
  • Annals of Medical Research
  • Annals of Medical Research

Dear readers,

Our journal is the official publication of Inonu University Medical Faculty and published uninterruptedly for 25 years. It was first published as the name of Inonu University Medical Journal and later as Journal of Turgut Ozal Medical Center. During its publication period, the journal accepted Turkish or English articles for publication.

Abstracting in an international index is just a paramount objective in the 25th year of the journal. Because of this goal, it was necessary to make a decision both in terms of journal name and publication language. It was important in this respect that the name of a general medical journal should be related to medicine again and it should be in English. For these reasons, the name of the journal was switched to Annals of Medical Research and its publication language is changed to in English. The logo of the journal was chosen as an apricot, which is the symbol of our city Malatya, the world capital of apricot. I hope the journal succeeds with its new name. Annals of Medical Research is published monthly.

Editor-in-Chief

 

Investigation of oxidative stress in experimental periodontitis treated with myricetin (p.3272-7)

Investigation of oxidative stress in experimental periodontitis treated with myricetin (p.3272-7)

Zehra Gulsoy1, Zeynep Pinar Keles Yucel2, Berrak Guven3, Umut Balli4
1Mamak Public Oral Health Center, Ankara, Turkey
2Department of Periodontology, Faculty of Dentistry, Giresun University, Giresun, Turkey
3Department of Biochemistry, Faculty of Medicine, Zonguldak Bulent Ecevit University, Zonguldak, Turkey
4Department of Periodontology, Faculty of Dentistry, Zonguldak Bulent Ecevit University, Zonguldak, Turkey
Copyright@Author(s) - Available online at www.annalsmedres.org
Content of this journal is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Abstract

Aim: The aim of this study was to investigate the effects of systemically applied myricetin on oxidative stress and antioxidant status in experimental periodontitis of rats.
Materials and Methods: 24 Wistar rats were used and randomly divided into three groups. Experimental periodontitis was induced by placing a silk ligature around first molars teeth of the rats for 15 days. Following removal of the ligatures, Group 1: saline; Group 2: myricetin and Group 3: doxycycline were administered systemically. Total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), superoxide dismutase (SOD) enzyme and malondialdehyde (MDA) levels in serum; and SOD and MDA levels in gingival tissue were determined by biochemical analysis.
Results: Serum TAS increased and serum TOS and OSI values decreased in myricetin and doxycycline treated groups compared to saline group (P0.016). Gingival tissue SOD activity was increased in the group treated with doxycycline compared with the group treated with saline (P0.016). MDA levels in both serum and gingival tissue samples were decreased in myricetin and doxycycline treated groups compared to saline group (P0.016).
Conclusion: The systemic administration of myricetin may be useful to diminish oxidative damage in periodontitis.

Keywords: Myricetin; oxidative stress; periodontal disease; periodontitis

 

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doi: 10.5455/annalsmedres.2020.02.124      

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Annals of Medical Research is the scientific official journal of the Inonu University Faculty of Medicine. It is published monthly. The essential aim of the Annals of Medical Research is to publish scientifically high quality clinical and experimental research articles on fields of medicine which can contribute to the literature data. In addition, review articles, case reports, editorials, letters to the editors and manuscripts on publication ethics and medical history, which can contribute to the education and practices of physicians and health sector professionals within the scope of the journal’s target audience and which can increase the level of scientific communication between the authors and readers, are included in the scope of the journal.

 

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