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Formerly Journal of Turgut Ozal Medical Center - ISSN 1300-1744

  • Annals of Medical Research

    Annals of Medical Research International Monthly Published Medical Journal

  • Annals of Medical Research

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  • Annals of Medical Research

    Annals of Medical Research indexed in TÜBİTAK/ULAKBİM Tıp Veri Tabanı

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  • Annals of Medical Research
  • Annals of Medical Research
  • Annals of Medical Research
  • Annals of Medical Research

Dear readers,

Our journal is the official publication of Inonu University Medical Faculty and published uninterruptedly for 25 years. It was first published as the name of Inonu University Medical Journal and later as Journal of Turgut Ozal Medical Center. During its publication period, the journal accepted Turkish or English articles for publication.

Abstracting in an international index is just a paramount objective in the 25th year of the journal. Because of this goal, it was necessary to make a decision both in terms of journal name and publication language. It was important in this respect that the name of a general medical journal should be related to medicine again and it should be in English. For these reasons, the name of the journal was switched to Annals of Medical Research and its publication language is changed to in English. The logo of the journal was chosen as an apricot, which is the symbol of our city Malatya, the world capital of apricot. I hope the journal succeeds with its new name. Annals of Medical Research is published monthly.



The localization of ERα and ERß in rat testis and epididymis  (p.2534-9)

The localization of ERα and ERß in rat testis and epididymis (p.2534-9)

Fatih Mehmet Gur1,  Ibrahim Aktas2
1Department of Histology and Embriyology, Faculty of Medicine, Nigde Omer Halis Demir University, Nigde, Turkey
2Department of Pharmacology, Faculty of Medicine, Adiyaman University, Adiyaman, Turkey
Copyright © 2020 by authors and Annals of Medical Research Publishing Inc.


Aim: It is an indisputable fact that estrogens are essential for the normal functioning of the male reproductive system. Although there are many studies investigating the localization of estrogen receptor α (ERα) and estrogen receptor ß (ERß) in the testis and epididymis, there is no consensus between the results of these studies. Therefore, in this study, it was aimed to investigate the ERα and ERß expression pattern in testis and epididymis using immunohistochemical methods.
Material and Methods: The testis and epididymis tissues removed from 3 adult rats after anesthetized with ether. Then the tissues fixed in Bouin's fixative. The tissues embedded in paraffin were cut 5 µm thickness with microtome and stained with immunohistochemical methods.
Results: In the testis, ERα-positive immunostaining was observed in the nuclei of peritubular myoid cells and in the cytoplasm of Leydig cells. The germ cells other than spermatogonium and spermatid were ERα-negative. ERβ-positive immunoreaction was detected in the nuclei of spermatogonia, peritubular myoid cells and Leydig cells. The cells in which ERα and ERβ positive immunostaining were seen most intensively were spermatogonia. ER (α and ß) positive immunostaining in the epididymis was observed in epithelial cells and interstitial stromal cells. Although most of the epithelial cells (principal, basal, apical) were ERα and ER β positive staining, others were negative.
Conclusion: The results obtained in this study showed that ERα and ERß are localized in somatic and germ cells in the testis and epithelial and stromal cells in the epididymis. In this study, it was observed that ERα and ERß staining intensity in spermatogoniums was higher than other cells. This result can be interpreted that estrogens perform their effects on the testis mainly through spermatogonia. The presence of ER (α and ß) in testis and epididymis, support the view that estrogens play an important role in the development and maintenance of male reproductive functions and fertility.

Keywords: Epididymis; estrogen receptor alpha; estrogen receptor beta; rat; testis 


doi: 10.5455/annalsmedres.2020.07.683           


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Annals of Medical Research is the scientific official journal of the Inonu University Faculty of Medicine. It is published monthly. The essential aim of the Annals of Medical Research is to publish scientifically high quality clinical and experimental research articles on fields of medicine which can contribute to the literature data. In addition, review articles, case reports, editorials, letters to the editors and manuscripts on publication ethics and medical history, which can contribute to the education and practices of physicians and health sector professionals within the scope of the journal’s target audience and which can increase the level of scientific communication between the authors and readers, are included in the scope of the journal.


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