• E-ISSN 2636-7688

Formerly Journal of Turgut Ozal Medical Center

  • Annals of Medical Research

    Annals of Medical Research International Monthly Published Medical Journal

  • Annals of Medical Research

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  • Annals of Medical Research

    Annals of Medical Research indexed in TÜBİTAK/ULAKBİM Tıp Veri Tabanı

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  • Annals of Medical Research
  • Annals of Medical Research
  • Annals of Medical Research
  • Annals of Medical Research

Dear Annals of Medical Research Readers

As of the end of March 2021, I have started to work as Chief Editor at Annals of Medical Research. Our journal is the official publication of Inonu University Medical Faculty and published uninterruptedly for 28 years.  Our Journal, which is online as an open access journal with monthly free access, is being scanned in many national and international indexes (ULAKBIM TR Dizin, Turkish Medline, EBSCO, Google Scholar, etc.). I would like to thank the Editors before me who contributed to this level. Our primary goal is to ensure the maintenance of this good state of the journal and to ensure that it is scanned in prestigious international indexes (Pubmed Central, SCI-Expended, etc.). In order to achieve these goals, it depends on the original research articles that can be cited and the articles published in our Journal to be cited sufficiently in other international journals. The contributions of our readers, reviewers and authors in achieving this goal are of great importance.

I hope to announce the news that we have reached our goals as soon as possible.

MD. Prof. Nevzat Erdil


Annals of Medical Research


The localization of ERα and ERß in rat testis and epididymis  (p.2534-9)

The localization of ERα and ERß in rat testis and epididymis (p.2534-9)

Fatih Mehmet Gur1,  Ibrahim Aktas2
1Department of Histology and Embriyology, Faculty of Medicine, Nigde Omer Halis Demir University, Nigde, Turkey
2Department of Pharmacology, Faculty of Medicine, Adiyaman University, Adiyaman, Turkey
Copyright © 2020 by authors and Annals of Medical Research Publishing Inc.


Aim: It is an indisputable fact that estrogens are essential for the normal functioning of the male reproductive system. Although there are many studies investigating the localization of estrogen receptor α (ERα) and estrogen receptor ß (ERß) in the testis and epididymis, there is no consensus between the results of these studies. Therefore, in this study, it was aimed to investigate the ERα and ERß expression pattern in testis and epididymis using immunohistochemical methods.
Material and Methods: The testis and epididymis tissues removed from 3 adult rats after anesthetized with ether. Then the tissues fixed in Bouin's fixative. The tissues embedded in paraffin were cut 5 µm thickness with microtome and stained with immunohistochemical methods.
Results: In the testis, ERα-positive immunostaining was observed in the nuclei of peritubular myoid cells and in the cytoplasm of Leydig cells. The germ cells other than spermatogonium and spermatid were ERα-negative. ERβ-positive immunoreaction was detected in the nuclei of spermatogonia, peritubular myoid cells and Leydig cells. The cells in which ERα and ERβ positive immunostaining were seen most intensively were spermatogonia. ER (α and ß) positive immunostaining in the epididymis was observed in epithelial cells and interstitial stromal cells. Although most of the epithelial cells (principal, basal, apical) were ERα and ER β positive staining, others were negative.
Conclusion: The results obtained in this study showed that ERα and ERß are localized in somatic and germ cells in the testis and epithelial and stromal cells in the epididymis. In this study, it was observed that ERα and ERß staining intensity in spermatogoniums was higher than other cells. This result can be interpreted that estrogens perform their effects on the testis mainly through spermatogonia. The presence of ER (α and ß) in testis and epididymis, support the view that estrogens play an important role in the development and maintenance of male reproductive functions and fertility.

Keywords: Epididymis; estrogen receptor alpha; estrogen receptor beta; rat; testis 


doi: 10.5455/annalsmedres.2020.07.683           


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Annals of Medical Research is the scientific official journal of the Inonu University Faculty of Medicine. It is published monthly. The essential aim of the Annals of Medical Research is to publish scientifically high quality clinical and experimental research articles on fields of medicine which can contribute to the literature data. In addition, review articles, case reports, editorials, letters to the editors and manuscripts on publication ethics and medical history, which can contribute to the education and practices of physicians and health sector professionals within the scope of the journal’s target audience and which can increase the level of scientific communication between the authors and readers, are included in the scope of the journal.


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