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Formerly Journal of Turgut Ozal Medical Center - ISSN 1300-1744

  • Annals of Medical Research



    Annals of Medical Research International Monthly Published Medical Journal

  • Annals of Medical Research

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  • Annals of Medical Research


    Annals of Medical Research indexed in TÜBİTAK/ULAKBİM Tıp Veri Tabanı

  • Annals of Medical Research


    Annals of Medical Research indexed in

  • Annals of Medical Research
  • Annals of Medical Research
  • Annals of Medical Research
  • Annals of Medical Research

Dear readers,

Our journal is the official publication of Inonu University Medical Faculty and published uninterruptedly for 25 years. It was first published as the name of Inonu University Medical Journal and later as Journal of Turgut Ozal Medical Center. During its publication period, the journal accepted Turkish or English articles for publication.

Abstracting in an international index is just a paramount objective in the 25th year of the journal. Because of this goal, it was necessary to make a decision both in terms of journal name and publication language. It was important in this respect that the name of a general medical journal should be related to medicine again and it should be in English. For these reasons, the name of the journal was switched to Annals of Medical Research and its publication language is changed to in English. The logo of the journal was chosen as an apricot, which is the symbol of our city Malatya, the world capital of apricot. I hope the journal succeeds with its new name. Annals of Medical Research is published monthly.

Editor-in-Chief

 

A comparative analysis of the effects of esmolol, lidocaine, nitroglycerin and placebo on hemodynamic response to extubation, and extubation quality and postoperative pain (p.2617-24)

A comparative analysis of the effects of esmolol, lidocaine, nitroglycerin and placebo on hemodynamic response to extubation, and extubation quality and postoperative pain (p.2617-24)

Gamze Kucukosman, Bengu Gulhan Aydin
Department of Anesthesiology and Reanimation, Faculty of Medicine, Zonguldak Bulent Ecevit University, Zonguldak, Turkey
Copyright © 2020 by authors and Annals of Medical Research Publishing Inc.

Abstract

Aim: To comparatively analyze and determine the effects of esmolol, lidocaine, and nitroglycerin on hemodynamic response to extubation, extubation quality and postoperative pain, based on the placebo effect.
Material and Methods: Our study design covers a prospective, randomized clinical trial in 120 patients who underwent intubation. Random division was applied onto the patients to obtain 4 groups: Esmolol, Lidocaine, Nitroglycerin, and Saline. In preparation for extubation; when the train-of-four (TOF) value reached 75% (basaline), study drugs were administered. When TOF ≥90%, the patients were extubated. Heart rate (HR) and mean blood pressure (MBP) records were taken prior to induction, when TOF 75% and 90, 1st, 3rd, and 5th. minutes after drugs were administered and extubation. Extubation time, quality, and postoperative pain values were recorded.
Results: When compared to the Placebo group based on post extubation measurements, the Esmolol group had no significant difference for MBP at any time but lower HR as recorded at the fifth minute (P:0.012). For both indicators, it significantly decreased according to pre- and post excubation records, with the Nitroglycerin group (P0.05). All the groups are indifferent at a statistical significance level for extubation quality. The Lidocain group had lower pain scores in the postoperative period for any specified time, compared to the Placebo (P0.05).
Conclusions: No superior agent was found in our study with regard to inhibition of the hemodynamic response to extubation, and its quality. Nonetheless, in order to limit the response esmolol and nitroglycerin were efficacious when used at the doses of 1.5 mg and 2 μg per kg, respectively. Lastly, the postoperative pain were lower in the Lidocaine group.

Keywords: Extubation quality; hemodynamic response; postoperative pain

 

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doi: 10.5455/annalsmedres.2020.05.514            

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Annals of Medical Research is the scientific official journal of the Inonu University Faculty of Medicine. It is published monthly. The essential aim of the Annals of Medical Research is to publish scientifically high quality clinical and experimental research articles on fields of medicine which can contribute to the literature data. In addition, review articles, case reports, editorials, letters to the editors and manuscripts on publication ethics and medical history, which can contribute to the education and practices of physicians and health sector professionals within the scope of the journal’s target audience and which can increase the level of scientific communication between the authors and readers, are included in the scope of the journal.

 

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