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Formerly Journal of Turgut Ozal Medical Center - ISSN 1300-1744

  • Annals of Medical Research

    Annals of Medical Research International Monthly Published Medical Journal

  • Annals of Medical Research

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  • Annals of Medical Research

    Annals of Medical Research indexed in TÜBİTAK/ULAKBİM Tıp Veri Tabanı

  • Annals of Medical Research

    Annals of Medical Research indexed in

  • Annals of Medical Research
  • Annals of Medical Research
  • Annals of Medical Research
  • Annals of Medical Research

Dear readers,

Our journal is the official publication of Inonu University Medical Faculty and published uninterruptedly for 25 years. It was first published as the name of Inonu University Medical Journal and later as Journal of Turgut Ozal Medical Center. During its publication period, the journal accepted Turkish or English articles for publication.

Abstracting in an international index is just a paramount objective in the 25th year of the journal. Because of this goal, it was necessary to make a decision both in terms of journal name and publication language. It was important in this respect that the name of a general medical journal should be related to medicine again and it should be in English. For these reasons, the name of the journal was switched to Annals of Medical Research and its publication language is changed to in English. The logo of the journal was chosen as an apricot, which is the symbol of our city Malatya, the world capital of apricot. I hope the journal succeeds with its new name. Annals of Medical Research is published monthly.



Re-irradiation results of fractionated stereotactic radiotherapy (FSRT) with cyberknife for locally-advanced nasopharengeal carcinoma (NPC) (p.2370-6)

Re-irradiation results of fractionated stereotactic radiotherapy (FSRT) with cyberknife for locally-advanced nasopharengeal carcinoma (NPC) (p.2370-6)

Ozlem Yetmen Dogan, Gokhan Yaprak, Fatih Demircioglu, Emriye Algul, Beyhan Ceylaner Bicakci, Hazan Ozyurt, Naciye Isik
Department of Radiation Oncology; Kartal Dr Lutfi Kirdar Training and Research Hospital, Istanbul, Turkey
Copyright © 2020 by authors and Annals of Medical Research Publishing Inc.


Aim: Recurrent nasopharyngeal carcinoma (NPC) after previous radiation therapy is a major problem. This study was conducted to determine the survival benefits and potential benefits of the effects of severe late toxicities by re-irradiation with fractionated stereotactic radiotherapy (FSRT).
Material and Methods: 2009-2018, treatment outcomes were evaluated retrospectively in 26 patients with local recurrent NPC were cured applying FSRT with Cyberknife. Five patients had metastatic disease and one had second recurrence was excluded from the research, remaining 20 patients were analyzed. Median agewas 52 years (range,28-80 years), re-treatment T stagewas; 6 (30%) T2, 5 (25%) T3, 9 (45%) T4.Median time from initial RT to recurrence was 22 months (range,8-159 mo.). The median re-irradiation FSRT dose was 30Gy in 5 fractions.
Results: Median follow-up was44 (22-179)months, the overall survival(OS) rate, local failure-free survival (LFFS ) and disease progression-free survival(DPFS) rate at 3 years were 89%,73% and 53%, respectively. All patients were evaluated for response after treatment; 9 (45%) had complete, 3 (15%) partial, 6 (%30) had no response.Univariate analysis demonstrated that; higher cumulative total radiotherapy dose, gross tumor volume and recurrent time interval were prognostic factors for LFFS. Recurrent time interval was also independent factor for DPFS and OS. The incidence of temporal lobe necrosis and trismus were 10% and 20%,respectively. One patient had grade 5 toxicity to treatment related bleeding.
Conclusion: Tumor dose coverage is critical for treating recurrent NPC and treatment linked death rate was vascular in nature. Fractionated stereotactic radiotherapy is promising treatment modality for recurrent NPC.

Keywords: Fractionated stereotactic radiotherapy; recurrent nasopharyngeal carcinoma; re-irradiation 



doi:  10.5455/annalsmedres.2020.05.493  


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Annals of Medical Research is the scientific official journal of the Inonu University Faculty of Medicine. It is published monthly. The essential aim of the Annals of Medical Research is to publish scientifically high quality clinical and experimental research articles on fields of medicine which can contribute to the literature data. In addition, review articles, case reports, editorials, letters to the editors and manuscripts on publication ethics and medical history, which can contribute to the education and practices of physicians and health sector professionals within the scope of the journal’s target audience and which can increase the level of scientific communication between the authors and readers, are included in the scope of the journal.



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