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Formerly Journal of Turgut Ozal Medical Center - ISSN 1300-1744

  • Annals of Medical Research



    Annals of Medical Research International Monthly Published Medical Journal

  • Annals of Medical Research

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  • Annals of Medical Research


    Annals of Medical Research indexed in TÜBİTAK/ULAKBİM Tıp Veri Tabanı

  • Annals of Medical Research


    Annals of Medical Research indexed in

  • Annals of Medical Research
  • Annals of Medical Research
  • Annals of Medical Research
  • Annals of Medical Research

Dear readers,

Our journal is the official publication of Inonu University Medical Faculty and published uninterruptedly for 25 years. It was first published as the name of Inonu University Medical Journal and later as Journal of Turgut Ozal Medical Center. During its publication period, the journal accepted Turkish or English articles for publication.

Abstracting in an international index is just a paramount objective in the 25th year of the journal. Because of this goal, it was necessary to make a decision both in terms of journal name and publication language. It was important in this respect that the name of a general medical journal should be related to medicine again and it should be in English. For these reasons, the name of the journal was switched to Annals of Medical Research and its publication language is changed to in English. The logo of the journal was chosen as an apricot, which is the symbol of our city Malatya, the world capital of apricot. I hope the journal succeeds with its new name. Annals of Medical Research is published monthly.

Editor-in-Chief

 

Investigation of antifungal, antibiofilm and anti-filamentation activities of biocides against Candida isolates (p.2041-6)

Investigation of antifungal, antibiofilm and anti-filamentation activities of biocides against Candida isolates (p.2041-6)

Ali Ozturk1, Olkar Abdulmajed2, Merve Aydin3
1Department of Medical Microbiology, Faculty of Medicine, Nigde Omer Halisdemir University, Nigde, Turkey
2Department of Medical Microbiology, Faculty of Medicine, Yuksek Ihtisas University, Ankara, Turkey
3Department of Medical Microbiology, Faculty of Medicine, KTO Karatay University, Konya, Turkey
Copyright © 2020 by authors and Annals of Medical Research Publishing Inc.

Abstract

Aim: This study was aimed to evaluate the antifungal, antibiofilm, and anti-filamentation activities of three commonly used biocides against clinical Candida isolates.
Material and Methods: The in vitro activities of benzalkonium chloride (BZC), chlorhexidine digluconate (CHX), and triclosan (TRC) were studied against three Candida (C. albicans, C. parapsilosis, and C. glabrata) isolates. The isolates were identified, using the germ tube test, Cornmeal agar, and ID32 C (bioMerieux, France) kit. Antifungal susceptibility of these isolates was determined using the broth microdilution method. Antibiofilm activity of biocides were assessed with a colorimetric method based on crystal violet. The effect of biocides on the ability of C. albicans to form hyphae was examined microscopically.
Results: The antifungal, antibiofilm, and anti-filamentation activities of biocides used were determined against Candida isolates. Antifungal activities of biocides against Candida isolates ranged from 1–4 µg/ml. The potent fungistatic effect of biocides tested was detected against Candida spp. at 1 µg/ml. All tested biocides showed good antifungal activity against Candida isolates. The results of the antibiofilm activity assay showed that the highest biofilm inhibition ratios were reported in BZC, CHX, and TRC (66%, 60.3%, and 58%, respectively) at 16 and 32 µg/ml. The lowest biofilm inhibition ratios were reported at MIC values for each biocide between 6% and 12%. In addition, the anti-filamentation activity of biocides tested was screened against C. albicans at concentrations of 1, 2, and 4 µg/ml of biocide and the inhibition rates varied from 10% to 59%.
Conclusions: Important information has been obtained about the fungistatic/fungicidal, antibiofilm activities, and effects on C. albicans micromorphology of the biocides used in this study.

Keywords: Antifungal; antibiofilm; anti-filamentation; biocides; candida 

  

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doi: 10.5455/annalsmedres.2020.05.478 

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Annals of Medical Research is the scientific official journal of the Inonu University Faculty of Medicine. It is published monthly. The essential aim of the Annals of Medical Research is to publish scientifically high quality clinical and experimental research articles on fields of medicine which can contribute to the literature data. In addition, review articles, case reports, editorials, letters to the editors and manuscripts on publication ethics and medical history, which can contribute to the education and practices of physicians and health sector professionals within the scope of the journal’s target audience and which can increase the level of scientific communication between the authors and readers, are included in the scope of the journal.

 

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