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Formerly Journal of Turgut Ozal Medical Center - ISSN 1300-1744

  • Annals of Medical Research



    Annals of Medical Research International Monthly Published Medical Journal

  • Annals of Medical Research

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  • Annals of Medical Research


    Annals of Medical Research indexed in TÜBİTAK/ULAKBİM Tıp Veri Tabanı

  • Annals of Medical Research


    Annals of Medical Research indexed in

  • Annals of Medical Research
  • Annals of Medical Research
  • Annals of Medical Research
  • Annals of Medical Research

Dear readers,

Our journal is the official publication of Inonu University Medical Faculty and published uninterruptedly for 25 years. It was first published as the name of Inonu University Medical Journal and later as Journal of Turgut Ozal Medical Center. During its publication period, the journal accepted Turkish or English articles for publication.

Abstracting in an international index is just a paramount objective in the 25th year of the journal. Because of this goal, it was necessary to make a decision both in terms of journal name and publication language. It was important in this respect that the name of a general medical journal should be related to medicine again and it should be in English. For these reasons, the name of the journal was switched to Annals of Medical Research and its publication language is changed to in English. The logo of the journal was chosen as an apricot, which is the symbol of our city Malatya, the world capital of apricot. I hope the journal succeeds with its new name. Annals of Medical Research is published monthly.

Editor-in-Chief

 

Predictive role of methylarginines in renal failure (p.2129-33)

Predictive role of methylarginines in renal failure (p.2129-33)

Fikret Akyurek, Gulperi Celik, Bahadir Ozturk
Department of Clinic Biochemistry, Faculty of Medicine, Selcuk Universty, Konya,Turkey

Copyright © 2020 by authors and Annals of Medical Research Publishing Inc.

Abstract

Aim: In this study, we aimed to investigate the role of methylarginines in renal failure and the process leading to failure. Acute Renal Failure (ARF) is defined as sudden onset, damage and loss of renal function. Chronic Kidney Disease (CKD) is generally defined as the presence of decreased renal function loss that persists for more than 3 months. Methylarginines are arginine derivatives which inhibit ischemia and vasoconstriction by inhibiting nitric oxide synthesis, causing ischemia and damage. Methylarginines are metabolized mainly in the kidney. Their metabolism is in the form of direct excretion and enzymatic degradation.
Material and Methods: The study was conducted from 2017 through 2018 in 89 patient (serum creatinine levels above 1.5 mg/dL) and 54 healthy control cases. Methylarginines were analyzed in positive mode from Turbo Ion Spray Electrospray (ESI) using ABSCIEX API 3200 High Performance Liquid Chromatography mass spectrometry (LC-MS / MS) instrument using C18 column. Urea and creatinine were analyzed by Beckman Coulter AU5800 Series. Results were evaluated with SPSS system.
Results: A significant difference was found in terms methylarginines urea and creatinine when patient and control groups compared. However, only creatinine and creatinine clearance values differences were found in patient groups in terms of acute and chronic renal failure (respectively, p = 0.001 for creatinine and p = 0.028 for creatinine clearance).There was no difference in terms of other parameters.
Conclusions: Methylarginines can be considered as new and high potential biomarkers for evaluating renal function. However, it is not considered to be adequate for show the prognosis of the disease

Keywords: ARF, CKD, ADMA, SDMA, Creatinine 

 

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doi: 10.5455/annalsmedres.2020.02.157

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Annals of Medical Research is the scientific official journal of the Inonu University Faculty of Medicine. It is published monthly. The essential aim of the Annals of Medical Research is to publish scientifically high quality clinical and experimental research articles on fields of medicine which can contribute to the literature data. In addition, review articles, case reports, editorials, letters to the editors and manuscripts on publication ethics and medical history, which can contribute to the education and practices of physicians and health sector professionals within the scope of the journal’s target audience and which can increase the level of scientific communication between the authors and readers, are included in the scope of the journal.

 

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