1Department of Cardiology, Adiyaman Training and research Hospital, Adiyaman, Turkey
2Department of Cardiology, Kahta Community Hospital, Adıyaman, Turkey
3Department of Cardiology, Faculty of Medicine, Istanbul Medeniyet University, Istanbul, Turkey
4Department of Cardiology, Mardin Community Hospital, Mardin, Turkey
Copyright © 2020 by authors and Annals of Medical Research Publishing Inc.
Aim: Platelet-to-lymphocyte ratio has been used as a determinant factor for coronary artery disease. Since platelet activation is central to the initiation of atherosclerosis, our goal was to evaluate the relationship between platelet-to-lymphocyte ratio and fractional flow reserve (FFR) values in the left anterior descending artery (LAD) with intermediate coronary stenosis.
Material and Methods: The present report encompassed 173 subjects having stable angina pectoris. These subjects were categorized into 2 groups: 91 subjects with a FFR less than or equal to 0.80 and 82 patients with a FFR greater than 0.80. The platelet-to-lymphocyte ratio of each subject was determined from the complete blood count. The two groups were evaluated for differences using a Student's unpaired t-test. A p-value of 0.05 was considered statistically significant.
Results: The average platelet-to-lymphocyte ratio value of subjects with a FFR less than or equal to 0.80 were significantly higher than those with a FFR greater than 0.80 ((115.5±38.0) vs. (103.8±38.9), p=0.04). The correlation between platelet-to-lymphocyte ratio with stenosis degree was significant (r= 0.22, p= 0.003).
Conclusion: Platelet-to-lymphocyte ratio was associated with a FFR measurement of equal or less than to 0.80 in subjects with stable angina pectoris.
Keywords: Fractional flow reserve; Stable angina pectoris; Platelet-to-lymphocyte ratio; Left anterior descending artery