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Formerly Journal of Turgut Ozal Medical Center - ISSN 1300-1744

  • Annals of Medical Research



    Annals of Medical Research International Monthly Published Medical Journal

  • Annals of Medical Research

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  • Annals of Medical Research


    Annals of Medical Research indexed in TÜBİTAK/ULAKBİM Tıp Veri Tabanı

  • Annals of Medical Research


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  • Annals of Medical Research
  • Annals of Medical Research
  • Annals of Medical Research
  • Annals of Medical Research

Dear readers,

Our journal is the official publication of Inonu University Medical Faculty and published uninterruptedly for 25 years. It was first published as the name of Inonu University Medical Journal and later as Journal of Turgut Ozal Medical Center. During its publication period, the journal accepted Turkish or English articles for publication.

Abstracting in an international index is just a paramount objective in the 25th year of the journal. Because of this goal, it was necessary to make a decision both in terms of journal name and publication language. It was important in this respect that the name of a general medical journal should be related to medicine again and it should be in English. For these reasons, the name of the journal was switched to Annals of Medical Research and its publication language is changed to in English. The logo of the journal was chosen as an apricot, which is the symbol of our city Malatya, the world capital of apricot. I hope the journal succeeds with its new name. Annals of Medical Research is published monthly.

Editor-in-Chief

 

Dynamic thiol / disulfide homeostasis in metabolically healthy obese adolescents (p.2186-90)

Dynamic thiol / disulfide homeostasis in metabolically healthy obese adolescents (p.2186-90)

Ozge Yuce1, Ozcan Erel2
1Department of Pediatric Endocrinology, Faculty of Medicine, Baskent University, Ankara, Turkey
2Department of Clinical Biochemistry, Faculty of Medicine, Yildirim Beyazit University, Ankara, Turkey

Copyright © 2020 by authors and Annals of Medical Research Publishing Inc.

Abstract

Aim: This study aim to discuss the possible role of oxidant-antioxidant balance in providing metabolic health in obese adolescents by determining the oxidant-antioxidant status.
Material and Methods: 98 metabolically healthy obese and 75 normal-weight adolescents participated in the study. Obese individuals were grouped according to the severity of obesity. Biochemical parameters including thiol/ disulfide homeostasis were analyzed. Serum native thiol (SH), total thiol (SH+SS) and disulfide (SS) concentrations were determined using a novel automated measurement method. Disulfide to native thiol ratio (SS/SH), disulfide to total thiol ratio(SS/(SH+SS)), and native thiol to total thiol ratio (SH/(SH + SS)) were calculated and were presented as percentage.
Results: Native and total thiol levels-as an antioxidative parameter-was significantly higher in obese adolescents compared to healthy-weight adolescents (p0.001). Native thiol/total thiol ratio was slightly higher in the obese group, but not statistically significant (p=0.4). Disulfide levels, disulfide/native thiol and disulfide/total thiol ratios were not different between the groups. We found that the levels of the antioxidant parameters, native thiol, and total thiol increased significantly along with the severity of the obesity, while other parameters remained comparable. We also found a significant increase in antioxidant parameters correlated with the severity of obesity (p0.001).
Conclusion: This study concluded that the increased antioxidant status and activity in obese adolescents may be related to the metabolic health.

Keywords: Thiol/Disulfide; obesity; adolescent; oxidative stress 

 

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doi: 10.5455/annalsmedres.2019.11.747     

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Annals of Medical Research is the scientific official journal of the Inonu University Faculty of Medicine. It is published monthly. The essential aim of the Annals of Medical Research is to publish scientifically high quality clinical and experimental research articles on fields of medicine which can contribute to the literature data. In addition, review articles, case reports, editorials, letters to the editors and manuscripts on publication ethics and medical history, which can contribute to the education and practices of physicians and health sector professionals within the scope of the journal’s target audience and which can increase the level of scientific communication between the authors and readers, are included in the scope of the journal.

 

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