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Formerly Journal of Turgut Ozal Medical Center - ISSN 1300-1744

  • Annals of Medical Research



    Annals of Medical Research International Monthly Published Medical Journal

  • Annals of Medical Research

    In publication or citation search, the name similarities of the authors, typographical errors and institutional changes can cause confusion. To prevent this, researchers need to obtain a descriptive ID. ORCID (Open Researcher and Contributor ID) is a researcher-specific international URI with a 16-digit number. You can register for free for individual ORCID at http://orcid.org. Please indicate the ORCID number of all authors when submitting your article.

  • Annals of Medical Research


    Annals of Medical Research indexed in TÜBİTAK/ULAKBİM Tıp Veri Tabanı

  • Annals of Medical Research


    Annals of Medical Research indexed in

  • Annals of Medical Research
  • Annals of Medical Research
  • Annals of Medical Research
  • Annals of Medical Research

Dear readers,

Our journal is the official publication of Inonu University Medical Faculty and published uninterruptedly for 25 years. It was first published as the name of Inonu University Medical Journal and later as Journal of Turgut Ozal Medical Center. During its publication period, the journal accepted Turkish or English articles for publication.

Abstracting in an international index is just a paramount objective in the 25th year of the journal. Because of this goal, it was necessary to make a decision both in terms of journal name and publication language. It was important in this respect that the name of a general medical journal should be related to medicine again and it should be in English. For these reasons, the name of the journal was switched to Annals of Medical Research and its publication language is changed to in English. The logo of the journal was chosen as an apricot, which is the symbol of our city Malatya, the world capital of apricot. I hope the journal succeeds with its new name. Annals of Medical Research is It is published monthly.

Editor-in-Chief
Cuneyt Kayaalp

 

In-vitro evaluation of the effects of tigecycline on annulus fibrosus and nucleus pulposus (p.1855-9)

In-vitro evaluation of the effects of tigecycline on annulus fibrosus and nucleus pulposus (p.1855-9)

Yasin Emre Kaya1, Ibrahim Yilmaz2, Numan Karaarslan3, Bulent Bilir4, Duygu Yasar Sirin5,
Hanefi Ozbek2
1Department of Orthopaedic and Traumatology, Faculty of Medicine, Abant Izzet Baysal University, Bolu, Turkey
2Department of Medical Pharmacology, Faculty of Medicine, Istanbul Medipol University, Istanbul, Turkey
3Department of Neurosurgery, Faculty of Medicine, Namik Kemal University, Tekirdag, Turkey
4Department of Internal Medicine, Faculty of Medicine, Namik Kemal University, Tekirdag, Turkey
5Department of Molecular Biology and Genetics, Faculty of Arts and Sciences, Namik Kemal University, Tekirdag, Turkey

Copyright © 2020 by authors and Annals of Medical Research Publishing Inc.

Abstract

Aim: This study aimed to examine the effects of tigecycline on primary cell cultures established using intervertebral disc tissues.
Material and Methods: Primary Annulus Fibrosus and Nucleus Pulposus cultures were obtained from human intervertebral disc tissue. Untreated samples served as the control group, and treated samples served as the study group. Treated and untreated samples were statistically evaluated using an alpha significance value of 0.05.
Results: Proliferation and gene expression decreased in the tigecycline administered cultures when compared to the control group samples (P 0.05).
Conclusion: Drugs used in clinics may have side effects other than those indicated in their package insert.

Keywords: Chondroadherin gene; cartilage oligomatrix protein; interleukin-1beta; intervertebral disc cell culture; matrix metalloproteinase; tigecycline

 

 

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doi: 10.5455/annalsmedres.2020.03.224        

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Inonu University Faculty of Medicine

Malatya, 44069

Turkey


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dergi@inonu.edu.tr

dergi@inonu.edu.tr


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Annals of Medical Research is the scientific official journal of the Inonu University Faculty of Medicine. It is published monthly. The essential aim of the Annals of Medical Research is to publish scientifically high quality clinical and experimental research articles on fields of medicine which can contribute to the literature data. In addition, review articles, case reports, editorials, letters to the editors and manuscripts on publication ethics and medical history, which can contribute to the education and practices of physicians and health sector professionals within the scope of the journal’s target audience and which can increase the level of scientific communication between the authors and readers, are included in the scope of the journal.

 

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