2Department of Medical Pharmacology, Faculty of Medicine, Istanbul Medipol University, Istanbul, Turkey
3Department of Neurosurgery, Faculty of Medicine, Namik Kemal University, Tekirdag, Turkey
4Department of Internal Medicine, Faculty of Medicine, Namik Kemal University, Tekirdag, Turkey
5Department of Molecular Biology and Genetics, Faculty of Arts and Sciences, Namik Kemal University, Tekirdag, Turkey
Copyright © 2020 by authors and Annals of Medical Research Publishing Inc.
Aim: This study aimed to examine the effects of tigecycline on primary cell cultures established using intervertebral disc tissues.
Material and Methods: Primary Annulus Fibrosus and Nucleus Pulposus cultures were obtained from human intervertebral disc tissue. Untreated samples served as the control group, and treated samples served as the study group. Treated and untreated samples were statistically evaluated using an alpha significance value of 0.05.
Results: Proliferation and gene expression decreased in the tigecycline administered cultures when compared to the control group samples (P 0.05).
Conclusion: Drugs used in clinics may have side effects other than those indicated in their package insert.
Keywords: Chondroadherin gene; cartilage oligomatrix protein; interleukin-1beta; intervertebral disc cell culture; matrix metalloproteinase; tigecycline