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Formerly Journal of Turgut Ozal Medical Center - ISSN 1300-1744

  • Annals of Medical Research



    Annals of Medical Research International Monthly Published Medical Journal

  • Annals of Medical Research

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  • Annals of Medical Research


    Annals of Medical Research indexed in TÜBİTAK/ULAKBİM Tıp Veri Tabanı

  • Annals of Medical Research


    Annals of Medical Research indexed in

  • Annals of Medical Research
  • Annals of Medical Research
  • Annals of Medical Research
  • Annals of Medical Research

Dear readers,

Our journal is the official publication of Inonu University Medical Faculty and published uninterruptedly for 25 years. It was first published as the name of Inonu University Medical Journal and later as Journal of Turgut Ozal Medical Center. During its publication period, the journal accepted Turkish or English articles for publication.

Abstracting in an international index is just a paramount objective in the 25th year of the journal. Because of this goal, it was necessary to make a decision both in terms of journal name and publication language. It was important in this respect that the name of a general medical journal should be related to medicine again and it should be in English. For these reasons, the name of the journal was switched to Annals of Medical Research and its publication language is changed to in English. The logo of the journal was chosen as an apricot, which is the symbol of our city Malatya, the world capital of apricot. I hope the journal succeeds with its new name. Annals of Medical Research is It is published monthly.

Editor-in-Chief
Cuneyt Kayaalp

 

The relationship between Ki-67 index and axillary lymph node metastasis in breast carcinoma (p.1956-60)

The relationship between Ki-67 index and axillary lymph node metastasis in breast carcinoma (p.1956-60)

Meric Emre Bostanci, Murat Can Mollaoglu, Kursat Karadayi
Department of Surgical Oncology, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey

Copyright © 2020 by authors and Annals of Medical Research Publishing Inc.

Abstract

Aim: Breast cancer is the most common type of cancer in women. The presence and number of metastatic lymph nodes in the axilla are the most significant prognostic factors in breast cancer. In addition, tumor size, lymphovascular invasion, perineural invasion, histopathological type and grade of the tumor are among the best-known prognostic factors. Ki-67 is expressed in G1, S, G2 and M phases of the cell cycle but not in the G0 phase, which allows it to be used as a marker for proliferating cells. The purpose of this study is to determine the relationship between Ki-67 Index and classical prognostic factors in breast cancer patients and to investigate its effect on axillary lymph node metastasis.
Material and Methods: 46 patients, who were diagnosed as breast carcinoma in Sivas Cumhuriyet University Medical Faculty Surgical Oncology Department and who underwent a modified radical mastectomy and axillary lymph node dissection between 2017 and 2019 were included in this study. Histological tumor type, stage, status of axillary lymph nodes and Ki-67 Index were evaluated retrospectively from the pathology reports of the patients. The patients were grouped under three categories according to Ki-67 Index.
Results: Regarding the grouping of the patients according to Ki-67 Index, the ones below 15% formed the first group, between 15-29% the second group, and above 30% the third group. The distribution of the patients according to negativity-positivity of axillary lymph node metastasis in the groups was as fallow: First group, 7 (41.2%) negative - 10 (58.8%) positive; Second group 4 (33.3%) negative - 8 (66.7%) positive; Third Group 3 (17.6%) negative - 14 (82.4%) positive. Of the 46 patients included in the study, 14 (30.4%) were negative for axillary lymph node metastasis and 32 (69.9%) were positive. In our study, the relationship between the increase of Ki-67 Index and axillary lymph node positivity was found to be statistically significant.
Conclusion: In this study, we investigated the relationship between Ki-67 Index and classical prognostic markers, especially lymph node metastasis. Proliferation is an important indicator used to predict prognosis and treatment response in breast cancer. In our study, Ki-67 Index, one of the cell proliferation markers, was found to be positively correlated with axillary lymph node metastasis and other prognostic factors. Therefore, Ki-67 Index was shown to be a significant prognostic indicator in breast cancer.

 

Keywords: Axillary lymph node; breast cancer; Ki-67

 

 

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doi: 10.5455/annalsmedres.2020.01.06      

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Annals of Medical Research is the scientific official journal of the Inonu University Faculty of Medicine. It is published monthly. The essential aim of the Annals of Medical Research is to publish scientifically high quality clinical and experimental research articles on fields of medicine which can contribute to the literature data. In addition, review articles, case reports, editorials, letters to the editors and manuscripts on publication ethics and medical history, which can contribute to the education and practices of physicians and health sector professionals within the scope of the journal’s target audience and which can increase the level of scientific communication between the authors and readers, are included in the scope of the journal.

 

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