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Formerly Journal of Turgut Ozal Medical Center - ISSN 1300-1744

  • Annals of Medical Research



    Annals of Medical Research International Monthly Published Medical Journal

  • Annals of Medical Research

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  • Annals of Medical Research


    Annals of Medical Research indexed in TÜBİTAK/ULAKBİM Tıp Veri Tabanı

  • Annals of Medical Research


    Annals of Medical Research indexed in

  • Annals of Medical Research
  • Annals of Medical Research
  • Annals of Medical Research
  • Annals of Medical Research

Dear readers,

Our journal is the official publication of Inonu University Medical Faculty and published uninterruptedly for 25 years. It was first published as the name of Inonu University Medical Journal and later as Journal of Turgut Ozal Medical Center. During its publication period, the journal accepted Turkish or English articles for publication.

Abstracting in an international index is just a paramount objective in the 25th year of the journal. Because of this goal, it was necessary to make a decision both in terms of journal name and publication language. It was important in this respect that the name of a general medical journal should be related to medicine again and it should be in English. For these reasons, the name of the journal was switched to Annals of Medical Research and its publication language is changed to in English. The logo of the journal was chosen as an apricot, which is the symbol of our city Malatya, the world capital of apricot. I hope the journal succeeds with its new name. Annals of Medical Research is It is published monthly.

Editor-in-Chief
Cuneyt Kayaalp

 

The diagnostic value of adrenomedullin and its relation with severity in patients with systolic heart failure (p.1972-6)

The diagnostic value of adrenomedullin and its relation with severity in patients with systolic heart failure (p.1972-6)

Nilgun Yildirim1, Abdulbaki Kumbasar2
1Department of Internal Medicine, Faculy of Medicine, Firat University, Elazig, Turkey
2Department of Internal Medicine, Faculy of Medicine, University of Health Sciences, Istanbul, Turkey

Copyright © 2020 by authors and Annals of Medical Research Publishing Inc.

Abstract

Aim: Adrenomedullin (ADM) is a vasodilator, natriuretic and antiproliferative peptide that lowers blood pressure and inhibits cell migration. The expression of cardiac ADM is increased in heart failure (HF). The objective of this study was to investigate and simultaneously compare the levels of probrain natriuretic peptide (pro-BNP) and ADM as a potential marker in patients with HF.
Material and Methods: In this study, plasma levels of probrain natriuretic peptide and ADM were investigated in 90 subjects with systolic heart failure and 90 healthy controls. The results were compared with appropriate statistical methods.
Results: ADM levels were increased in patients with systolic HF with mean levels of 87.7 (81.4–99.7) pg/mL in HF group and 70.8 (65.2–78.7) pg/mL in healthy controls (p 0.001). Elevated ADM levels in HF were found to demonstrate a positive correlation with New York Heart Association (NYHA) functional classification (r = 0.94, p 0.001) and pulmonary arterial systolic pressure (PASP) (r = 0.44, p 0.001), and a negative correlation with left ventricular ejection fraction (LVEF) (r = -0.50, p 0.001) and creatinine clearance (GFR) (r = -0.21, p = 0.045). The area under the curve for HF was similar for ADM (1.00) and pro-BNP (1.00).
Conclusion: The study showed that ADM may have a diagnostic value in indicating systolic HF. In addition, it was found that ADM levels increased with worsening HF and were positively correlated with NYHA class, pro-BNP and PASP, while ADM levels were negatively correlated with LVEF, GFR.

Keywords: Adrenomedullin; systolic heart failure; probrain natriuretic peptide

 

 

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doi: 10.5455/annalsmedres.2019.12.891    

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Annals of Medical Research is the scientific official journal of the Inonu University Faculty of Medicine. It is published monthly. The essential aim of the Annals of Medical Research is to publish scientifically high quality clinical and experimental research articles on fields of medicine which can contribute to the literature data. In addition, review articles, case reports, editorials, letters to the editors and manuscripts on publication ethics and medical history, which can contribute to the education and practices of physicians and health sector professionals within the scope of the journal’s target audience and which can increase the level of scientific communication between the authors and readers, are included in the scope of the journal.

 

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