• E-ISSN 2636-7688
  • Call Us: +90 422 341 06 60 / 1224
  • Email Us: dergi@inonu.edu.tr

Formerly Journal of Turgut Ozal Medical Center - ISSN 1300-1744

  • Annals of Medical Research



    Annals of Medical Research International Monthly Published Medical Journal

  • Annals of Medical Research

    In publication or citation search, the name similarities of the authors, typographical errors and institutional changes can cause confusion. To prevent this, researchers need to obtain a descriptive ID. ORCID (Open Researcher and Contributor ID) is a researcher-specific international URI with a 16-digit number. You can register for free for individual ORCID at http://orcid.org. Please indicate the ORCID number of all authors when submitting your article.

  • Annals of Medical Research


    Annals of Medical Research indexed in TÜBİTAK/ULAKBİM Tıp Veri Tabanı

  • Annals of Medical Research


    Annals of Medical Research indexed in

  • Annals of Medical Research
  • Annals of Medical Research
  • Annals of Medical Research
  • Annals of Medical Research

Dear readers,

Our journal is the official publication of Inonu University Medical Faculty and published uninterruptedly for 25 years. It was first published as the name of Inonu University Medical Journal and later as Journal of Turgut Ozal Medical Center. During its publication period, the journal accepted Turkish or English articles for publication.

Abstracting in an international index is just a paramount objective in the 25th year of the journal. Because of this goal, it was necessary to make a decision both in terms of journal name and publication language. It was important in this respect that the name of a general medical journal should be related to medicine again and it should be in English. For these reasons, the name of the journal was switched to Annals of Medical Research and its publication language is changed to in English. The logo of the journal was chosen as an apricot, which is the symbol of our city Malatya, the world capital of apricot. I hope the journal succeeds with its new name. Annals of Medical Research is It is published monthly.

Editor-in-Chief
Cuneyt Kayaalp

 

eNOS gene polymorphısms and transıtıonal cell cancer of the bladder (p.2004-10)

eNOS gene polymorphısms and transıtıonal cell cancer of the bladder (p.2004-10)

Aziz Toker1, Erkan Erkan1, Fatma Sinem Hocaoglu Emre2, Ugur Yucetas1
1Clinic of Urology, Istanbul Education and Reseach Hospital, Istanbul, Turkey
2Department of Nutrition and Dietetics, Beykent University, Istanbul, Turkey


Copyright © 2020 by authors and Annals of Medical Research Publishing Inc.

Abstract

Aim: In this case-control study, we examined the association between two types of eNOS gene polymorphisms (intron 4 a/b and Glu298Asp) and transitional cell carcinoma (TCC) of the bladder.
Nitric Oxide (NO) is a free radical that plays a key role in various physiological and pathophysiological processes, particularly in the circulatory system. Endothelial Nitric Oxide Synthase (eNOS), as a member of NOS family, is the enzyme, responsible for the physiological production of nitric oxide in the endothelium. Polymorphisms of eNOS have been related to increased risk for different types of cancers.
Material and Methods: A total of 64 patients with bladder TCC and 80 controls with similar epidemiological characteristics of patients group were evaluated and compared in terms of eNOS gene polymorphisms of two different types ((intron 4 a/b and Glu298Asp). Following DNA isolation from the blood samples, eNOS gene was replicated via PCR. The genomic distribution of two types of eNOS polymorphism was determined by gel electrophoresis following the process of restriction, for both groups.
Results: The alleles most commonly observed in patient group were “ab” for intron 4 (OR= 1.80, 95% CI: 0.71-4.64; P=0.20) and “GT” for Glu298Asp polymorphisms (OR= 1.65, 95% CI: 0.85-3.22; P=0.14). Neither bladder cancer risk nor disease grade was associated with these polymorphisms.
Conclusions: This study suggests that the intron 4 a/b and Glu298Asp eNOS gene polymorphisms are not associated with bladder cancer susceptibility. However, it is mandatory to conduct further trials with more patients to confirm these findings and to evaluate the association between bladder cancer and eNOS gene polymorphisms.

Keywords: Bladder cancer; Glu298Asp polymorphism; intron 4 a/b  polymorphism; Nitric oxide synthase; Nitric oxide synthase polymorphism

 

 

DOWNLOAD
doi: 10.5455/annalsmedres.2020.01.039       

DownloadXML


Contact us

+90 422 341 06 60 / 1224 - University

+90 422 341 06 60 Department


Location

Inonu University Faculty of Medicine

Malatya, 44069

Turkey


Send us email

dergi@inonu.edu.tr

dergi@inonu.edu.tr


demo

Annals of Medical Research is the scientific official journal of the Inonu University Faculty of Medicine. It is published monthly. The essential aim of the Annals of Medical Research is to publish scientifically high quality clinical and experimental research articles on fields of medicine which can contribute to the literature data. In addition, review articles, case reports, editorials, letters to the editors and manuscripts on publication ethics and medical history, which can contribute to the education and practices of physicians and health sector professionals within the scope of the journal’s target audience and which can increase the level of scientific communication between the authors and readers, are included in the scope of the journal.

 

Recent News

Links

Certificate of General Impact Factor

Email Newsletter

Sign up for the latest Inonu University Our new article, updates....