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Formerly Journal of Turgut Ozal Medical Center - ISSN 1300-1744

  • Annals of Medical Research



    Annals of Medical Research International Monthly Published Medical Journal

  • Annals of Medical Research

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  • Annals of Medical Research


    Annals of Medical Research indexed in TÜBİTAK/ULAKBİM Tıp Veri Tabanı

  • Annals of Medical Research


    Annals of Medical Research indexed in

  • Annals of Medical Research
  • Annals of Medical Research
  • Annals of Medical Research
  • Annals of Medical Research

Dear readers,

Our journal is the official publication of Inonu University Medical Faculty and published uninterruptedly for 25 years. It was first published as the name of Inonu University Medical Journal and later as Journal of Turgut Ozal Medical Center. During its publication period, the journal accepted Turkish or English articles for publication.

Abstracting in an international index is just a paramount objective in the 25th year of the journal. Because of this goal, it was necessary to make a decision both in terms of journal name and publication language. It was important in this respect that the name of a general medical journal should be related to medicine again and it should be in English. For these reasons, the name of the journal was switched to Annals of Medical Research and its publication language is changed to in English. The logo of the journal was chosen as an apricot, which is the symbol of our city Malatya, the world capital of apricot. I hope the journal succeeds with its new name. Annals of Medical Research is It is published monthly.

Editor-in-Chief
Cuneyt Kayaalp

 

Effect of sugammadex on recovery from ketamine anesthesia: An experimental study (p.1601-5)

Effect of sugammadex on recovery from ketamine anesthesia: An experimental study (p.1601-5)

Selcuk Kayir1, Guvenc Dogan1, Ozgur Yagan1, Volkan Hanci2
1Hitit University, Faculty of Mecicine, Department of Anaesthesiology, Corum, Turkey
2Dokuz Eylul University, Faculty of Medicine, Department of Anaesthesiology, Izmir, Turkey

Copyright © 2020 by authors and Annals of Medical Research Publishing Inc.

Abstract

Aim: Previous studies have shown cyclodextrins bind to a variety of medications. The hypothesis in our study is to determine whether or not sugammadex interacts with the lipophilic medication of ketamine to shorten the effect duration and ensure earlier recovery.
Material and Methods: The study used 24 adult male Sprague-Dawley rats. Rats were randomly divided into 4 equal groups. Each rat was administered 75 mg/kg ketamine intraperitoneal (ip) bolus and then in the fifth minute rats was administered sugammadex at appropriate doses for their group through the lateral vein in the tail. Group C (control group) were administered 15 mL/kg physiologic serum (PS) (n=6), Group Sgdx 16 were administered 16 mg/kg sugammadex (n=6), Group Sgdx 100 were administered 100 mg/kg sugammadex (n=6) and Group Sgdx 1000 were administered 1000 mg/kg sugammadex (n=6). The heart rate, respiratory rate and recovery durations of the rats were recorded.
Results: The recovery duration in the Sgdx 100 group was statistically significantly shorter compared to the control group (p=0.026), while the recovery duration in the Sgdx 1000 group was statistically significantly shorter than the control group (p0.001) and the Sgdx 16 group (p=0.015). Heart rate was statistically significantly low in the Sgdx 1000 group compared to the control group (p0.05). Respiratory rates were similar.
Conclusion: Our study showed that 100 mg/kg and 1000 mg/kg sugammadex doses significantly shortened recovery. We conclude that there is a need for more research about the interaction between ketamine and sugammadex.

Keywords: Cyclodextrin; ketamine; recovery; sugammadex 

 

 

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doi: 10.5455/annalsmedres.2020.03.219   

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Annals of Medical Research is the scientific official journal of the Inonu University Faculty of Medicine. It is published monthly. The essential aim of the Annals of Medical Research is to publish scientifically high quality clinical and experimental research articles on fields of medicine which can contribute to the literature data. In addition, review articles, case reports, editorials, letters to the editors and manuscripts on publication ethics and medical history, which can contribute to the education and practices of physicians and health sector professionals within the scope of the journal’s target audience and which can increase the level of scientific communication between the authors and readers, are included in the scope of the journal.

 

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