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Formerly Journal of Turgut Ozal Medical Center - ISSN 1300-1744

  • Annals of Medical Research



    Annals of Medical Research International Monthly Published Medical Journal

  • Annals of Medical Research

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  • Annals of Medical Research


    Annals of Medical Research indexed in TÜBİTAK/ULAKBİM Tıp Veri Tabanı

  • Annals of Medical Research


    Annals of Medical Research indexed in

  • Annals of Medical Research
  • Annals of Medical Research
  • Annals of Medical Research
  • Annals of Medical Research

Dear readers,

Our journal is the official publication of Inonu University Medical Faculty and published uninterruptedly for 25 years. It was first published as the name of Inonu University Medical Journal and later as Journal of Turgut Ozal Medical Center. During its publication period, the journal accepted Turkish or English articles for publication.

Abstracting in an international index is just a paramount objective in the 25th year of the journal. Because of this goal, it was necessary to make a decision both in terms of journal name and publication language. It was important in this respect that the name of a general medical journal should be related to medicine again and it should be in English. For these reasons, the name of the journal was switched to Annals of Medical Research and its publication language is changed to in English. The logo of the journal was chosen as an apricot, which is the symbol of our city Malatya, the world capital of apricot. I hope the journal succeeds with its new name. Annals of Medical Research is It is published monthly.

Editor-in-Chief
Cuneyt Kayaalp

 

High serum S-100B protein levels within the first 36 hours of acute ischemic stroke predicts high NIHSS scores (p.1675-80)

High serum S-100B protein levels within the first 36 hours of acute ischemic stroke predicts high NIHSS scores (p.1675-80)

Tugba Yoruk Hazar1, Bijen Nazliel2, Asli Akyol Gurses2, Hale Batur Caglayan2, Ceyla Irkec3
1Clinic of Neurology, Bakirkoy Municipality Medical Center, Istanbul, Turkey
2Department of Neurology, Faculty of Medicine, Gazi University, Ankara, Turkey
3Clinic of Neurology, Lokman Hekim Akay Hospital, Ankara, Turkey

Copyright © 2020 by authors and Annals of Medical Research Publishing Inc.

Abstract

Aim: The aim of the present study was to evaluate serum levels of S-100B which is an acidic calcium-binding protein within the first 36 hours following an acute ischemic stroke and to determine the correlation between S-100B levels and National Institutes of Health Stroke Scale (NIHSS) scores.
Material and Methods: Fifty patients with ischemic stroke (25 male, 25 female; mean age=64) and 30 healthy volunteers (14 male, 16 female; mean age=61) serving as age and sex matched controls were included in this study. Venous blood samples were taken within the first 36 hours following the acute stroke. The quantitative determination of S-100B in serum was carried out using an enzyme linked immunosorbent assay.
Results: Patients with acute ischemic stroke had significantly higher serum S-100B protein concentrations (42 pg/ml) than those of normal controls (31.5 pg/ml) (p0.001). S-100B concentrations were correlated with NIHSS scores (r=0.443; p=0.001), which is considered an indicator of the degree of neurological deficit.
Conclusion: The present study demonstrates that S-100B concentrations in both the large artery atherosclerosis (LAA), cardio embolic infarct (CEI) subtypes of acute stroke are increased in the early phases of stroke and are correlated with NIHSS scores upon admission. S-100B appears to be a valuable biomarker of ongoing brain injury.

Keywords: Cerebral infarction; stroke; S-100B Protein; S-100B Calcium Binding Protein beta Subunit

 

 

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doi: 10.5455/annalsmedres.2020.12.903 

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Annals of Medical Research is the scientific official journal of the Inonu University Faculty of Medicine. It is published monthly. The essential aim of the Annals of Medical Research is to publish scientifically high quality clinical and experimental research articles on fields of medicine which can contribute to the literature data. In addition, review articles, case reports, editorials, letters to the editors and manuscripts on publication ethics and medical history, which can contribute to the education and practices of physicians and health sector professionals within the scope of the journal’s target audience and which can increase the level of scientific communication between the authors and readers, are included in the scope of the journal.

 

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