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Formerly Journal of Turgut Ozal Medical Center - ISSN 1300-1744

  • Annals of Medical Research



    Annals of Medical Research International Monthly Published Medical Journal

  • Annals of Medical Research

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  • Annals of Medical Research


    Annals of Medical Research indexed in TÜBİTAK/ULAKBİM Tıp Veri Tabanı

  • Annals of Medical Research


    Annals of Medical Research indexed in

  • Annals of Medical Research
  • Annals of Medical Research
  • Annals of Medical Research
  • Annals of Medical Research

Dear readers,

Our journal is the official publication of Inonu University Medical Faculty and published uninterruptedly for 25 years. It was first published as the name of Inonu University Medical Journal and later as Journal of Turgut Ozal Medical Center. During its publication period, the journal accepted Turkish or English articles for publication.

Abstracting in an international index is just a paramount objective in the 25th year of the journal. Because of this goal, it was necessary to make a decision both in terms of journal name and publication language. It was important in this respect that the name of a general medical journal should be related to medicine again and it should be in English. For these reasons, the name of the journal was switched to Annals of Medical Research and its publication language is changed to in English. The logo of the journal was chosen as an apricot, which is the symbol of our city Malatya, the world capital of apricot. I hope the journal succeeds with its new name. Annals of Medical Research is It is published monthly.

Editor-in-Chief
Cuneyt Kayaalp

 

Gallic acid liposome and powder gels improved wound healing in wistar rats (p. 2720-7)

Gallic acid liposome and powder gels improved wound healing in wistar rats (p. 2720-7)

Ozkan Karatas1, Fikret Gevrek2
1Tokat Gaziosmanpaşa University, Faculty of Dentistry, Department of Periodontology, Tokat, Turkey
2Tokat Gaziosmanpaşa University, Faculty of Medicine, Department of Histology and Embryology, Tokat, Turkey

Abstract

Aim: Gallic acid is an anti-inflammatory and antioxidant agent which could provide beneficial effects in preventing periodontal inflammation and improve wound healing. The present study aimed to evaluate the effects of gallic acid on experimental palatal wound model in Wistar rats.
Material and Methods: 60 female Wistar rats were divided into three main study groups as the control group (C, n=24), gallic acid powder gel administered group (GP, n=18), and gallic acid liposome administered group (GL, n=18). Standardized palatal wounds of 5-mm diameter were created in all rats. Control rats received vehicle gel, and the other groups received either GP or GL gels. Control rats were sacrificed on days 0, 7, 14, and 21. GP and GL groups were sacrificed on days 7, 14, and 21. Hematoxylin-eosin staining was performed, and fibroblast cell counts and inflammatory cell infiltration in the wound area were evaluated. Transforming growth factor (TGF)-β expressions were determined via immunohistochemistry.
Results: C, GP, and GL groups had a similar decrease in wound area apart from 21st day, which GL had significantly lower wound area compared to the control group. Unhealed wound area was significantly lower on the 14th and 21st days in gallic acid groups. GP and GL groups had significantly higher fibroblast cell counts on all days compared to the C group. GL had significantly highest counts even compared to GP groups. Inflammatory cell infiltration was higher on the 7th day compared to14th and 21st days in all groups. Gallic acid groups exhibited lower inflammatory cell counts on 7th and 21st days. TGF-β levels significantly increased in GP and GL groups on 7th and 14th days.
Conclusion: Within limitations of the present study, it can be concluded that gallic acid in both powder and liposome forms increased fibroblast cell counts and decreased late inflammation along with increased TGF-β expressions in the wound healing process.

Keywords: Anti-inflammatory; antioxidants; gallic acid; wound healing

 

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10.5455/annalsmedres.2019.05.301

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Annals of Medical Research is the scientific official journal of the Inonu University Faculty of Medicine. It is published monthly. The essential aim of the Annals of Medical Research is to publish scientifically high quality clinical and experimental research articles on fields of medicine which can contribute to the literature data. In addition, review articles, case reports, editorials, letters to the editors and manuscripts on publication ethics and medical history, which can contribute to the education and practices of physicians and health sector professionals within the scope of the journal’s target audience and which can increase the level of scientific communication between the authors and readers, are included in the scope of the journal.

 

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