Investigation of the effects of tigecycline, a semi-synthetic derivative of minocycline, on chondrocyte cultures

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Yasin Emre Kaya
Numan Karaarslan
Ibrahim Yilmaz
Duygu Yasar Sirin
Onur Yaman
Hanefi Ozbek
Ozkan Ates

Abstract

Aim: Although antibiotics are generally well-tolerated, they may have cytotoxic effects. The present randomized, double-blind, in vitro study aimed to investigate the effects of tigecycline on cartilage tissue cells and the extracellular matrix.Material and Methods: Cartilage tissues of patients (n = 8) were used for the preparation of primary cell cultures. Tigecycline-treated cell cultures served as the study group. Non-treated cell cultures served as the control group. Analyses were performed at 0, 24, 48, and 72 h in both groups. The results obtained were statistically evaluated. The alpha significance value was determined to be 0.05.Results: Proliferation remained unchanged in the tigecycline-treated cell cultures. The gene expressions of the markers involved in anabolic pathways increased in the tigecycline-treated cell cultures. The results obtained were statistically significant (P 0.05). Conclusion: Although tigecycline had no toxic effect on the chondrocyte cell cultures and caused no damage to the extracellular matrix, the present study was performed in an in vitro environment.

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How to Cite
Emre Kaya, Y., Karaarslan, N., Yilmaz, I., Yasar Sirin, D., Yaman, O., Ozbek, H., & Ates, O. (2021). Investigation of the effects of tigecycline, a semi-synthetic derivative of minocycline, on chondrocyte cultures . Annals of Medical Research, 27(4), 1082–1087. Retrieved from https://annalsmedres.org/index.php/aomr/article/view/727
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