Computed tomography and magnetic resonance imaging features for differentiating functioning from non-functioning adrenal lesions

Main Article Content

Derya Koseoglu
Mazhar Muslum Tuna
Narin Nasiroglu Imga
Bercem Aycicek
Mehtap Navdar Basaran
Cagdas Senel
Altug Tuncel
Dilek Berker
Serdar Guler

Abstract

Aim: It is not well known whether the radiological features of adenomas differ between functioning and non-functioning adrenal lesions (NFAL). The aim of this study was to evaluate the characteristic features of computed tomography (CT) and magnetic resonance imaging (MRI) characteristics among functioning and non-functioning adrenal lesions.
Material and Methods: This retrospective study included 89 patients with functioning adrenal lesions and 148 patients with NFAL, whose CT or MRI findings were present. Group 1 included patients with functioning adrenal lesions and group 2 patients with NFAL.
Results: In patients with functioning adrenal mass, adenoma size (p:0.001), unenhanced and early-enhanced Hounsfield units (HU) (p<0.001) were significantly higher compared to those with NFAL. Among the patients with functioning adrenal mass; Cushing’s syndrome, pheochromocytoma and primary hyperaldosteronism were diagnosed in 34, 32 and 23 patients, respectively. Mean early-
enhanced HU was higher in all functioning groups compared to NFAL (p<0.001, all). ROC analysis showed 80% specificity and 82.7% sensitivity for determining functioning adrenal masses with an early-enhanced CT attenuation value of 27 HU. On T1-weighted images functioning adrenal lesions were more commonly hypointense than NFAL (p=0.02).
Conclusion: This study reveals that functioning adrenal lesions might be differentiating from NFAL using CT features. Especially early-enhanced CT attenuation, which is elevated in all functioning adrenal mass forms, may be used effectively for this purpose.

Downloads

Download data is not yet available.

Article Details

How to Cite
Koseoglu, D., Tuna, M. M., Imga, N. N., Aycicek, B., Basaran, M. N., Senel, C., Tuncel, A., Berker, D., & Guler, S. (2021). Computed tomography and magnetic resonance imaging features for differentiating functioning from non-functioning adrenal lesions. Annals of Medical Research, 28(12), 2207–2212. Retrieved from https://annalsmedres.org/index.php/aomr/article/view/4002
Section
Original Articles

Most read articles by the same author(s)