Endotrophin levels in clinically-stable chronic obstructive pulmonary disease

Authors

  • Ozgur Altun Department of Internal Medicine, Prof. Dr. Cemil Tascioglu City Hospital, Istanbul, Turkey
  • Yucel Arman Department of Internal Medicine, Prof. Dr. Cemil Tascioglu City Hospital, Istanbul, Turkey
  • Nur Karakutuk Yuztas Department of Internal Medicine, Prof. Dr. Cemil Tascioglu City Hospital, Istanbul, Turkey
  • Selay Arslan Department of Internal Medicine, Prof. Dr. Cemil Tascioglu City Hospital, Istanbul, Turkey
  • Ayca Zeynep Kutlu Department of Emergency Medicine, Istanbul University Cerrahpasa Faculty of Medicine, Istanbul, Turkey
  • Pinar Saner Demir Department of Internal Medicine, Prof. Dr. Cemil Tascioglu City Hospital, Istanbul, Turkey
  • Murat Akarsu Department of Internal Medicine, Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey
  • Tufan Tukek Department of Internal Medicine, Faculty of Medicine, Istanbul University, Istanbul, Turkey

Keywords:

CRP, chronic obstructive pulmonary disease, endotrophin, extracellular matrix, inflammation

Abstract

Aim: Chronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation and permanent airflow limitations due to stenosis of the small airways. The role of the extracellular matrix (ECM) structure and its reshaping is gaining importance. Endotrophin is a division product formed during construction of type VI collagen. The aim of this study was to research the correlation between endotrophin and the stable COPD pathophysiology.
Materials and Methods: The study included 90 clinically-stable COPD patients and 38 participants without COPD. The demographic data, respiratory function tests and endotrophin levels of patients were recorded and statistically evaluated.
Results: Endotrophin levels were significantly high in COPD patients compared to healthy controls (p<0.001). Though there was a positive correlation between endotrophin and CRP (r=0.229, p=0.031), there was no correlation with FEV-1, FVC, mMRC dyspnea score, 6-minute walking test distance and GOLD degree.
Conclusion: Endotrophin was identified to be high in clinically stable COPD cases. This elevation appears to be associated with continuing inflammation in COPD. This correlation may guide prognosis studies for COPD and ensure the opportunity to develop new treatment strategies targeting endotrophin.

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Published

2021-12-23

How to Cite

Altun, O., Arman, Y., Yuztas, N. K., Arslan, S., Kutlu, A. Z., Demir, P. S., Akarsu, M., & Tukek, T. (2021). Endotrophin levels in clinically-stable chronic obstructive pulmonary disease. Annals of Medical Research, 28(12), 2145–2149. Retrieved from https://annalsmedres.org/index.php/aomr/article/view/3991

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Original Articles

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