Factors effecting the development of sentinel lymph node metastasis in clinical early-stage breast cancers (cT1-2N0): Clinical significance of primary tumor – skin distance

Authors

  • Levent Zirek Department of General Surgery, Cumhuriyet University Medical Faculty Hospital, Sivas, Turkey
  • Azmi Lale Department of Surgical Oncology, Aydin State Hospital, Aydin, Turkey
  • Merve Zirek Department of Biochemistry, Faculty of Medicine, Cumhuriyet University Hospital, Sivas, Turkey
  • Hatice Nur Lale Department of Public Health, Elazig Provincial Health Directorate, Elazig, Turkey
  • Ali Cihan Yildirir Department of General Surgery, Cumhuriyet University Medical Faculty Hospital, Sivas, Turkey
  • Erhan Aygen Department of General Surgery, Firat University Medical Faculty Hospital, Elazig, Turkey

Keywords:

Axillary node metastasis, c-erbB2/HER2-neu, distance from skin, lymphovascular invasion, sentinel lymph node metastasis predictors

Abstract

Aim: It was aimed to determine the demographic, clinicopathological and radiological predictors that may be effective in the development of sentinel lymph node (SLN) metastasis in patients with clinical early-stage breast cancer (cT1-2N0).
Materials and Methods: 178 patients were included in the study. Demographic, clinicopathological and radiological characteristics of the patients were recorded. Among these, there were age, neutrophil / lymphocyte ratio (NLR), HER2, estrogen receptor (ER) and progesterone receptor (PR), proliferation index (Ki- 67), morphological grade, molecular subtype, histopathological subtype, tumor size and localization, multifocality and multicentricity, nipple-areola complex (NAC) infiltration, perineural invasion (PNI), lymphatic invasion (LI), vascular invasion (VI), primary tumor -breast skin distance (DFS).
Results: Larger tumor size, HER-2 positivity, grade 3 histopathology, LI, VI, PNI, and closer DFS were found to be significant in univariate regression analyzes. In ROC analysis, the optimum cut-off value for DFS was found to be 13.5mm. In multivariant regression analyzes, HER-2 positivity, LI, PNI and ≤13.5mm DFS were found as independent SLN metastasis predictors.
Conclusion: Closer DFS, HER-2 positivity, LI and PNI are very strong predictors in patients with clinical early-stage breast cancer that must be taken into account in the development of SLN metastasis in cT1-2N0 breast cancers. These factors can guide clinicians to take accurate decisions in the treatment process.

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Published

2021-11-24

How to Cite

Zirek, L., Lale, A., Zirek, M., Lale, H. N., Yildirir, A. C., & Aygen, E. (2021). Factors effecting the development of sentinel lymph node metastasis in clinical early-stage breast cancers (cT1-2N0): Clinical significance of primary tumor – skin distance. Annals of Medical Research, 28(11), 2071–2079. Retrieved from https://annalsmedres.org/index.php/aomr/article/view/3978

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