Levels of interleukin-8 and catalase have correlations with zinc in healthy adults: Implications for inflammatory conditions

Authors

  • Ganiyu Olatunbosun Arinola Department of Immunology, University of Ibadan, Nigeria
  • Fabian Victory Edem Department of Immunology, University of Ibadan, Nigeria

Keywords:

Cytokines, inflammation, intracellular infections, micronutrient Zn, phagocytosis

Abstract

Aim: To determine the relationship between Zinc levels with different aspects of innate immunity [percentage leucocyte migration (%LM), intracellular killing (%NBT), plasma inflammatory cytokines (IL-6) and IL-8), plasma antioxidant enzymes (catalase, superoxide dismutase, myeloperoxidase, hydrogen peroxide) and nitric oxide] among healthy Nigerians.
Material and Methods: In 50 healthy adults, two phagocytic indices [percentage leucocyte migration (%LM) and intracellular killing (%NBT)] were determined by microscopy; two inflammatory cytokines [Plasma interleukin 6 (IL-6) and 8 (IL-8)] were assessed using ELISA; respiratory burst indices [plasma catalase (CAT), superoxide dismutase (SOD), myeloperoxidase (MPO), hydrogen peroxide (H2O2) and nitric oxide (NO)] were evaluated by spectrophotometry. Zinc (Zn) was determined using Atomic Absorption Spectrometry. Phagocytic indices, cytokines and respiratory burst indices were correlated with plasma Zn levels using Spearmans Correlation analysis at P <0.05.
Results: The result of the study shows that plasma IL-8 level had negative correlation with Zn level while catalase had positive correlation with Zn level in healthy adults.
Conclusion: These findings suggest that potential mechanism of Zn during innate immunity include production of antioxidant catalase enzyme and reduction of IL-8 inflammatory cytokine.
Recommendation: These findings raise the possibility that Zn supplementation or Zn containing diets may be beneficial to individuals with inflammatory conditions.

Downloads

Published

2021-11-24

How to Cite

Arinola, G. O., & Edem, F. V. (2021). Levels of interleukin-8 and catalase have correlations with zinc in healthy adults: Implications for inflammatory conditions. Annals of Medical Research, 28(11), 1957–1960. Retrieved from https://annalsmedres.org/index.php/aomr/article/view/3959

Issue

Section

Original Articles

Similar Articles

You may also start an advanced similarity search for this article.