α-Galactosidase levels in irritable bowel syndrome subtypes and quality of life of patients

Authors

  • Tuba Soysal Department of Internal Medicine, Faculty of Medicine, Duzce University, Duzce, Turkey
  • Fatih Ermis Department of Gastroenterology, Faculty of Medicine, Duzce University, Duzce, Turkey
  • Handan Ankarali Department of Biostatistics, Faculty of Medicine, Duzce University, Duzce, Turkey

Keywords:

Alpha-galactosidase, irritable bowel syndrome, quality of life

Abstract

Aim: There is a requirement for a reliable serologic marker that can be used for the diagnosis of Irritable Bowel Syndrome (IBS). The aim of our study was to research whether serum levels of Alpha-galactosidase (AG) is associated with IBS and to assess quality of life (QOL) of IBS patients.
Materials and Methods: 110 adult patients who were diagnosed with IBS were evaluated. 90 patients and 25 healthy volunteers were
included. Patients were classified into subtypes: IBS-Diarrhea (IBS-D), IBS-Constipation (IBS-C), IBS-Mixed (IBS-M), and 30 patients were
enrolled for each group. We administered the Short Form 36 (SF-36) to participants to evaluate QOL. Serum AG levels of participants was determined.
Results: The mean AG levels of IBS-C and control group were significantly lower than the other groups (p<0.05). The SF-36 questionnaire scores, except for the vitality and mental health domains, were higher significantly in the control group compared to IBS patients (p<0.05). The mean scores of IBS subtypes were similar. In addition, the mean physical functioning score of the control group was higher in comparison with the IBS-D group significantly (p<0.05).
Conclusion: Our study has shown that IBS impairs QOL in patients. In addition, we suggest that future studies needed for the role of AG deficiency in IBS patients.

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Published

2021-10-20

How to Cite

Soysal, T., Ermis, F., & Ankarali, H. (2021). α-Galactosidase levels in irritable bowel syndrome subtypes and quality of life of patients. Annals of Medical Research, 28(10), 1881–1886. Retrieved from https://annalsmedres.org/index.php/aomr/article/view/3944

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Section

Original Articles