Negative correlation between TNF-α and triglyceride levels in patients with cerebral infarction


  • Hikmet Sacmaci Department of Neurology, Faculty of Medicine, Bozok University, Yozgat, Turkey
  • Murat Cakir Department of Physiology, Faculty of Medicine, Bozok University, Yozgat, Turkey
  • Seda Sabah Ozcan Department of Medical Biology, Faculty of Medicine, Celal Bayar University, Manisa, Turkey


Cerebral infarction, inflammation response, triglyceride, tumor necrosis factor alpha


Aim: To investigate the interactions between tumor necrosis factor-alpha (TNF-α) and blood lipid levels in patients with acute
cerebral infarction.
Materials and Methods: A total of 43 cerebral infarction patients who applied to the neurology and emergency department of our faculty were included in cross-sectional matched case-control study, and the results were compared with 41 controls who had similar age and comorbidities. In addition to fasting serum lipids, serum glucose, C-reactive protein and hemogram were analyzed as well. Classification of infarct was made. An enzyme-linked immunosorbent test was used to determine baseline plasma TNF-α levels at the time of first admission and potential correlations between the groups were analyzed.
Results: Compared to the control group, the cerebral ischemia group had a higher median TNF-α level (23.53; range, 21.74-43.29 ng/L vs. 23.00; range, 20.62-37.34 ng/L); however, the difference was not significant (p > 0.05). Groups were similar regarding blood lipid values (p > 0.05). In the patient group, TNF-α level showed a negative correlation with triglyceride (TG) and TG / HDL cholesterol (HDL-C) (rho= -0.319 p= 0.037 and rho= -0.321 p= 0.036), whereas no significant correlation was determined in the control group (p > 0.05), on the other hand plasma level of TNF-α was positively correlated with the National Health Stroke Scale score (rho = 0.455 p = 0.002).
Conclusions: Our cross-sectional study revealed an interaction between decreased TG and TG / HDL-C and a high concentration of TNF-α in cerebral infarction for the first time. The importance of our finding is that it provides useful preliminary information, which is necessary for further research in this field.




How to Cite

Sacmaci, H., Cakir, M., & Ozcan, S. S. (2021). Negative correlation between TNF-α and triglyceride levels in patients with cerebral infarction. Annals of Medical Research, 28(8), 1583–1588. Retrieved from



Original Articles