• E-ISSN 2636-7688

Formerly Journal of Turgut Ozal Medical Center

Association between serum gamma-glutamyltransferase levels and hyperuricemia (p.597-601)

Association between serum gamma-glutamyltransferase levels and hyperuricemia (p.597-601)

Seckin Ozgur Tekeli, Feyza Yagmur Tekeli, Esin Eren, Necat Yilmaz
Department of Medical Biochemistry, Antalya Education and Research Hospital, Antalya, Turkey
Copyright@Author(s) - Available online at www.annalsmedres.org
Content of this journal is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Abstract

Aim: Although the the contribution of gamma-glutamyltransferase (GGT) to hyperuricemia (hUA) has been previously shown in literature, there is not any study showing the contribution of GGT to hUA in a Turkish population. The aim of this study was to investigate both the association between GGT and uric acid (UA) and the contribution of GGT to hUA in the Turkish population.
Materials and Methods: This retrospective study was conducted in Antalya, Turkey. A total of 14049 subjects (5521 males and 8528 females) aged > 40 years were recruited and divided into four subgroups according to serum GGT quartiles. Patient demographic data and laboratory results of biochemical parameters were obtained from electronic medical records. Linear regression analysis was applied to GGT quartiles with UA and binary logistic regression analysis was applied to GGT quartiles with hUA.
Results: Firstly, serum UA levels were increased across GGT quartiles (p 0.001). Linear regression models showed GGT in the fourth quartile was strong associated with a 0.22 mmol/L (95% confidence interval (CI) 0.16- 0.29, p = 0.001) increase in UA after adjustment. Logistic regression analysis revealed that compared with subjects in the lowest GGT quartile, the adjusted odds ratio (OR) for hyperuricemia in the fourth quartile was 2.62 (95% CI 2.27- 3.01, p = 0.001) after adjustment for age, sex, creatinine, total cholesterol (TC), high density lipoprotein (HDL) cholesterol, triglyceride (TG), glycosylated hemoglobin (HbA1c) and alanine aminotransferase (ALT).
Conclusions: Serum GGT is closely associated with serum UA and might contributes greatly to hUA.

Keywords: Cardiovascular disease; Gamma-glutamyl transferase; uric acid

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doi: 10.5455/annalsmedres.2020.02.152  

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Annals of Medical Research is the scientific official journal of the Inonu University Faculty of Medicine. It is published monthly. The essential aim of the Annals of Medical Research is to publish scientifically high quality clinical and experimental research articles on fields of medicine which can contribute to the literature data. In addition, review articles, case reports, editorials, letters to the editors and manuscripts on publication ethics and medical history, which can contribute to the education and practices of physicians and health sector professionals within the scope of the journal’s target audience and which can increase the level of scientific communication between the authors and readers, are included in the scope of the journal.

 

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